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首页> 外文期刊>Journal of applied toxicology >Distribution and biomarkers of carbon-14-labeled fullerene C-60 ([C-14(U)]C-60) in female rats and mice for up to 30 days after intravenous exposure
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Distribution and biomarkers of carbon-14-labeled fullerene C-60 ([C-14(U)]C-60) in female rats and mice for up to 30 days after intravenous exposure

机译：静脉暴露后长达30天，碳14标记的富勒烯C-60（[C-14（U）] C-60）在雌性大鼠和小鼠中的分布和生物标志物

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A comprehensive distribution study was conducted in female rats and mice exposed to a suspension of uniformly carbon-14-labeled C-60 ([C-14(U)]C-60). Rodents were administered [C-14(U)]C-60 (similar to 0.9 mg kg(-1) body weight) or 5% polyvinylpyrrolidone-saline vehicle alone via a single tail vein injection. Tissues were collected at 1 h and 1, 7, 14 and 30 days after administration. A separate group of rodents received five daily injections of suspensions of either [C-14(U)]C-60 or vehicle with tissue collection 14 days post exposure. Radioactivity was detected in over 20 tissues at all time points. The highest concentration of radioactivity in rodents at each time point was in liver, lungs and spleen. Elimination of [C-14(U)]C-60 was < 2% in urine and feces at any 24 h time points. [C-14(U)]C-60 and [C-14(U)]C-60-retinol were detected in liver of rats and together accounted for similar to 99% and similar to 56% of the total recovered at 1 and 30 days postexposure, respectively. The blood radioactivity at 1 h after [C-14(U)]C-60 exposure was fourfold higher in rats than in mice; blood radioactivity was still in circulation at 30 days post [C-14(U)]C-60 exposure in both species (<1%). Levels of oxidative stress markers increased by 5 days after exposure and remained elevated, while levels of inflammation markers initially increased and then returned to control values. The level of cardiovascular marker von Willebrand factor, increased in rats, but remained at control levels in mice. This study demonstrates that [C-14(U)]C-60 is retained in female rodents with little elimination by 30 days after i.v. exposure, and leads to systemic oxidative stress. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：在暴露于均匀碳14标记的C-60（[C-14（U）] C-60）悬浮液的雌性大鼠和小鼠中进行了全面的分布研究。通过单次尾静脉注射单独给啮齿类动物服用[C-14（U）] C-60（约0.9 mg kg（-1）体重）或5％聚乙烯基吡咯烷酮-盐水载体。给药后1小时，1、7、14和30天收集组织。另一组啮齿动物在暴露后14天每天接受五次[C-14（U）] C-60或媒介物悬浮液注射，并收集组织。在所有时间点都在20多个组织中检测到放射性。在每个时间点，啮齿动物中放射性最高的浓度是在肝脏，肺部和脾脏中。在任何24小时的时间尿液和粪便中[C-14（U）] C-60的消除率均小于2％。在大鼠肝脏中检测到[C-14（U）] C-60和[C-14（U）] C-60-视黄醇，在1时的回收率中占总回收率的99％和56％和暴露后30天。 [C-14（U）] C-60暴露后1 h，大鼠的血液放射性比小鼠高四倍。在两种物种中，[C-14（U）] C-60暴露后30天，血液放射性仍处于循环中（<1％）。暴露后5天，氧化应激标志物的水平升高，并保持升高，而炎症标志物的水平最初升高，然后恢复到对照值。心血管标志物von Willebrand因子的水平在大鼠中升高，但在小鼠中保持在对照水平。这项研究表明，[C-14（U）] C-60被保留在雌性啮齿动物中，静脉注射后30天几乎没有消除。暴露，并导致全身性氧化应激。版权所有（c）2015 John Wiley＆Sons，Ltd.

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