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首页> 外文期刊>Journal of applied toxicology >Changes in RANKL and osteoprotegerin expression after chronic exposure to indoor air pollution as a result of cooking with biomass fuel
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Changes in RANKL and osteoprotegerin expression after chronic exposure to indoor air pollution as a result of cooking with biomass fuel

机译：使用生物质燃料烹饪导致长期暴露于室内空气污染后RANKL和骨保护素表达的变化

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The impact of indoor air pollution as a result of cooking with unprocessed biomass on membrane-bound and serum receptor activator of nuclear factor-kappa ligand 1 (RANKL), its soluble decoy receptor osteoprotegerin (OPG) and osteoclast precursor CD14(+)CD16(+) monocytes was investigated. Seventy-four pre-menopausal women from eastern India using biomass and 65 control women who cooked with cleaner liquefied petroleum gas were enrolled. PM10 and PM2.5 levels in their indoor air were measured with real-time aerosol monitors. The levels of membrane-bound RANKL on leukocytes and percentage CD14(+)CD16(+) monocytes in the subjects' blood were assayed by flow cytometry. Soluble RANKL and OPG in serum were measured by ELISA. The results showed that PM10 and PM2.5 levels were significantly higher in the indoor air of biomass-using households. Compared with the control women, the levels of CD4(+) and CD19(+) lymphocytes and circulating granulocytes with elevated levels of membrane-bound RANKL were higher in biomass users. The serum levels of RANKL were increased by 41% whereas serum OPG was reduced by 22% among biomass users. The absolute number of CD14(+)CD16(+) monocytes was significantly increased in biomass users than the control women. After controlling for potential confounders, PM10 and PM2.5 levels were found to be positively associated with leukocyte and serum RANKL and CD14(+)CD16(+) monocyte levels, but negatively with serum OPG. From these results, we can conclude that chronic exposure to biomass smoke increased membrane-bound and soluble RANKL and circulating osteoclast precursors but decreased OPG, suggesting an increased risk of bone resorption and consequent osteoporosis in biomass-exposed women of a child-bearing age. Copyright (C) 2015 John Wiley & Sons, Ltd.
机译：使用未加工的生物质烹饪导致的室内空气污染对核因子-κ配体1（RANKL），其可溶性诱饵受体骨保护素（OPG）和破骨细胞前体CD14（+）CD16（）的膜结合和血清受体活化剂的影响+）研究了单核细胞。来自印度东部的74名绝经前妇女使用了生物质，有65名对照妇女用清洁的液化石油气烹饪。使用实时气溶胶监测仪测量室内空气中的PM10和PM2.5水平。通过流式细胞术测定受试者血液中白细胞的膜结合RANKL水平和受试者血液中CD14（+）CD16（+）单核细胞的百分比。通过ELISA测定血清中的可溶性RANKL和OPG。结果表明，使用生物质的家庭的室内空气中的PM10和PM2.5含量显着较高。与对照组女性相比，生物量使用者中具有较高的膜结合RANKL水平的CD4（+）和CD19（+）淋巴细胞和循环粒细胞水平更高。生物量使用者中，RANKL的血清水平提高了41％，而血清OPG降低了22％。生物量使用者中CD14（+）CD16（+）单核细胞的绝对数量比对照女性显着增加。在控制了潜在的混杂因素之后，发现PM10和PM2.5水平与白细胞和血清RANKL和CD14（+）CD16（+）单核细胞水平呈正相关，而与血清OPG呈负相关。从这些结果可以得出结论，长期暴露于生物质烟气会增加膜结合和可溶性RANKL和循环破骨细胞前体的含量，但降低OPG，这表明育龄妇女暴露于生物质的女性的骨吸收风险增加，从而导致骨质疏松。版权所有（C）2015 John Wiley＆Sons，Ltd.

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