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首页> 外文期刊>Journal of applied toxicology >Therapy and prophylaxis of inhaled biological toxins.
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Therapy and prophylaxis of inhaled biological toxins.

机译：吸入性生物毒素的治疗和预防。

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This review highlights the current lack of therapeutic and prophylactic treatments for use against inhaled biological toxins, especially those considered as potential biological warfare (BW) or terrorist threats. Although vaccine development remains a priority, the use of rapidly deployable adjunctive therapeutic or prophylactic drugs could be life-saving in severe cases of intoxication or where vaccination has not been possible or immunity not established. The current lack of such drugs is due to many factors. Thus, methods involving molecular modelling are limited by the extent to which the cellular receptor sites and mode of action and structure of a toxin need to be known. There is also our general lack of knowledge of what effect individual toxins will have when inhaled into the lungs - whether and to what extent the action will be cell speci fi c and cytotoxic or rather an acute in fl ammatory response requiring the use of immunomodulators. Possible sources of speci fi c high-af fi nity toxin antagonists being investigated include monoclonal antibodies, selected oligonucleotides (aptamers) and derivatized dendritic polymers (dendrimers). The initial selection of suitable agents of these kinds can be made using cytotoxicity assays involving cultured normal human lung cells and a range of suitable indicators. The possibility that a mixture of selected antibody, aptamer or dendrimer-based materials for one or more toxins could be delivered simultaneously as injections or as inhaled aerosol sprays should be investigated. Copyright Crown Copyright 2003. Reproduced with the permission of Her Majesty's Stationery Office. Published by John Wiley & Sons, Ltd.
机译：这篇评论强调了目前缺乏用于吸入生物毒素的治疗和预防方法，尤其是那些被认为是潜在的生物战（BW）或恐怖分子威胁的毒素。尽管疫苗的开发仍然是当务之急，但是在严重中毒或无法接种疫苗或无法建立免疫力的情况下，使用快速部署的辅助治疗或预防药物可能会挽救生命。当前缺乏这种药物是由于许多因素。因此，涉及分子建模的方法受到需要知道细胞受体位点以及作用方式和毒素结构的程度的限制。我们还普遍缺乏关于个体毒素吸入到肺中后会产生什么作用的知识，即该作用是否发生以及在何种程度上是细胞特异性和细胞毒性作用，或者是需要使用免疫调节剂的急性呼吸道反应。正在研究的特定高亲和力毒素拮抗剂的可能来源包括单克隆抗体，选定的寡核苷酸（适体）和衍生化的树枝状聚合物（树枝状聚合物）。可以使用涉及培养的正常人肺细胞和一系列合适指标的细胞毒性测定法初步选择这些合适的药剂。应该研究一种或多种毒素的选定抗体，适体或树状聚合物基材料的混合物可同时作为注射剂或吸入气雾剂递送的可能性。版权Crown版权2003。经英国with下文具办公室许可复制。由John Wiley＆Sons，Ltd.出版

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