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首页> 外文期刊>Journal of applied toxicology >Genistein treatment protects mice from ionizing radiation injury.
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Genistein treatment protects mice from ionizing radiation injury.

机译：金雀异黄素治疗可保护小鼠免受电离辐射伤害。

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摘要

The radioprotective and behavioral effects of an acute administration of the iso fl avone genistein (4',5,7-trihydroxy fl avone) were investigated in adult CD2F1 male mice. Mice were administered a single subcutaneous (s.c.) dose of genistein either 24 h or 1 h before a lethal dose of gamma radiation (9.5-Gy of cobalt-60 at 0.6 Gy min(-1)). Mice received saline, PEG-400 vehicle or genistein at 3.125, 6.25, 12.5, 25, 50, 100, 200, or 400 mg kg(-1) body weight. For mice treated 24 h before irradiation there was a signi fi cant increase in 30-day survival for animals receiving genistein doses of 25 to 400 mg kg(-1) (p < 0.001). In contrast, the 30-day survival rates of mice treated with genistein 1 h before irradiation were not signi fi cantly different from those of the vehicle control group. Additionally, the acute toxicity of genistein was evaluated in non-irradiated male mice administered a single s.c. injection of saline, vehicle, or genistein at 100, 200 or 400 mg kg(-1). At these genistein doses there were no adverse effects, compared with controls, on locomotor activity, grip strength, motor coordination, body weight, testes weight, or histopathology. These results demonstrate that a single s.c. administration of the fl avonoid genistein at non-toxic doses provides protection against acute radiation injury. Published in 2003 by John Wiley & Sons, Ltd.
机译：在成年CD2F1雄性小鼠中研究了异黄酮染料木黄酮（4'，5,7-三羟基黄酮）的急性给药的辐射防护和行为效应。在致死剂量的伽马射线辐射（0.6 Gy min（-1）时9.5-Gy的60钴）之前24小时或1小时给小鼠皮下（s.c.）剂量的染料木黄酮。小鼠接受3.125、6.25、12.5、25、50、100、200或400 mg kg（-1）体重的盐水，PEG-400载体或染料木黄酮。对于接受辐射前24小时治疗的小鼠来说，接受染料木黄酮剂量为25至400 mg kg（-1）的动物在30天存活率方面有显着提高（p <0.001）。相反，在辐射前1h用染料木黄酮处理的小鼠30天生存率与媒介物对照组没有显着差异。另外，在单只皮下注射未辐照的雄性小鼠中评价了染料木黄酮的急性毒性。以100、200或400 mg kg（-1）注射盐水，媒介物或染料木黄酮。与对照组相比，在这种染料木黄酮剂量下，对运动能力，抓地力，运动协调，体重，睾丸重量或组织病理学没有不利影响。这些结果表明，一个s.c。黄酮类染料木黄酮以无毒剂量给药可防止急性放射损伤。 John Wiley＆Sons，Ltd.于2003年出版。

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