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首页> 外文期刊>Journal of applied toxicology >Parabens, oestrogenicity, underarm cosmetics and breast cancer: a perspective on a hypothesis.
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Parabens, oestrogenicity, underarm cosmetics and breast cancer: a perspective on a hypothesis.

机译：对羟基苯甲酸酯，雌激素，腋下化妆品和乳腺癌：假说的观点。

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摘要

A recent review by Darbre (2003) published in this journal (J. Appi. Toxicol. 23: 89-95) has attracted public and scientific interest that requires perspective, particularly on the use of esters of p-hydroxybenzoic acid (parabens) as preservatives in underarm cosmetics. Although parabens are generally regarded as safe, recent reports suggest that they are oestrogenic in a variety of in vitro (including MCF7 and ZR-75-1 human breast cancer cell lines) and in vivo tests for oestrogenicity (uterotrophic assays in both rat and mouse). There are also recent reports of adverse reproductive and developmental outcomes in rodent toxicity studies. Of interest is the lack of activity by the oral route but clear activity by the subcutaneous and topical routes, which is of some relevance to the use of underarm cosmetics. There would seem to be a case now to supplement these emerging toxicity data with longer term regulatory standard tests examining other oestrogenic endpoints and at least to consider these findingsin more up-to-date risk assessments specific for cosmetic use. Further, there are few data on the use of underarm cosmetics and the risk of breast cancer, and although one recent retrospective interview-based study found no association there is a need for more thorough investigation taking into account the type of chemicals used. Darbre has forwarded a hypothesis and called for further work to establish whether or not the use of underarm cosmetics (particularly containing oestrogenic formulants) contributes to the rising incidence of breast cancer. It would seem prudent to conduct this work because the current database is sparse and the effects of long-term low-level exposures to weakly oestrogenic chemicals on human health, particularly their application to the underarm and the risks of breast cancer, are unknown. The role of oestrogens in breast cancer, however, is undisputed.
机译：Darbre（2003）最近发表在该杂志上的评论（J. Appi。Toxicol。23：89-95）引起了公众和科学的兴趣，需要引起人们的关注，特别是对羟基苯甲酸（对羟基苯甲酸酯）酯的使用。腋下化妆品中的防腐剂。尽管通常认为对羟基苯甲酸酯是安全的，但最近的报道表明它们在多种体外（包括MCF7和ZR-75-1人乳腺癌细胞系）和体内雌激素测试（在大鼠和小鼠中均进行营养测试）中具有雌激素性）。最近也有关于啮齿动物毒性研究中不利的生殖和发育结果的报道。令人感兴趣的是口服途径缺乏活性，但皮下和局部途径缺乏明显的活性，这与腋下化妆品的使用有关。现在似乎有一种情况，可以通过检查其他雌激素终点的长期监管标准测试来补充这些新兴的毒性数据，并至少在针对化妆品使用的最新风险评估中考虑这些发现。此外，关于腋下化妆品的使用和患乳腺癌的风险的数据很少，尽管最近一项基于回顾性访谈的研究发现没有关联，但仍需要对使用的化学物质类型进行更彻底的调查。 Darbre提出了一个假设，并呼吁进一步开展工作，以确定使用腋下化妆品（特别是含有雌激素制剂）是否会导致乳腺癌的发病率上升。进行这项工作似乎是审慎的做法，因为当前的数据库稀少，长期低水平暴露于弱雌激素化学物质对人体健康的影响，尤其是其在腋下的应用以及患乳腺癌的风险尚不清楚。然而，雌激素在乳腺癌中的作用是无可争议的。

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