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首页> 外文期刊>Journal of applied toxicology >Effects of a single intratracheal administration of phenanthraquinone on murine lung.
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Effects of a single intratracheal administration of phenanthraquinone on murine lung.

机译：气管内施用蒽醌对小鼠肺的影响。

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Although several studies have reported that diesel exhaust particles (DEP) affect cardiorespiratory health in animals and humans, the responsible components in DEP for the effects remain to be defined. Diesel exhaust particles contain quinones that can catalyse the generation of reactive oxygen species, resulting in the induction of oxidative stress. Oxidative stress can correlate with a variety of diseases and health effects. In the present study, we investigated the effects of phenanthraquinone--a relatively abundant quinone in DEP--on lung inflammation and the local expression of cytokine proteins in mice as a measure of oxidative damage. The animals were randomized into two experimental groups that received vehicle or phenanthraquinone by intratracheal instillation. The cellular profiles of bronchoalveolar lavage fluid (BALF) and local expression of cytokines were evaluated 24 and 48 h after the instillation. Phenanthraquinone challenge revealed an increase in the numbers of neutrophils and eosinophils in BALF as compared to vehicle challenge (P < 0.05 at 48 h post-instillation). Phenanthraquinone induced the lung expression of interleukin (IL)-5 and eotaxin 48 h and 24 h after the challenge, respectively. These results indicate that intratracheal exposure to phenanthraquinone induces recruitment of inflammatory cells, at least partly, through the local expression of IL-5 and eotaxin.
机译：尽管有几项研究报道了柴油机废气颗粒（DEP）影响动物和人类的心肺健康，但DEP中负责这种作用的主要成分仍有待确定。柴油机排气颗粒包含醌，该醌可催化活性氧的产生，从而导致氧化应激的产生。氧化应激可能与多种疾病和健康影响相关。在本研究中，我们调查了菲蒽醌（DEP中相对丰富的醌）对小鼠肺部炎症和细胞因子蛋白局部表达的影响，以此作为氧化损伤的一种量度。将动物随机分为两个实验组，通过气管内滴注接受媒介物或菲醌。滴注后24和48小时，评估支气管肺泡灌洗液（BALF）的细胞概况和细胞因子的局部表达。与媒介物激发相比，苯蒽醌激发显示出BALF中嗜中性粒细胞和嗜酸性粒细胞数量增加（滴注后48小时，P <0.05）。激发后48小时和24小时，蒽醌诱导白细胞介素（IL）-5和嗜酸性粒细胞趋化因子的肺表达。这些结果表明气管内暴露于菲蒽醌至少部分地通过IL-5和嗜酸性粒细胞趋化因子的局部表达诱导炎症细胞的募集。

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