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首页> 外文期刊>Journal of applied toxicology >Regulation of manganese accumulation in perinatally exposed rat pups.
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Regulation of manganese accumulation in perinatally exposed rat pups.

机译：围产期暴露的大鼠幼仔中锰积累的调节。

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The risk of manganese (Mn)-related ill effects in the neonate has been the topic of several investigations because in formula-fed infants Mn intake is much higher than in breast-fed infants. In the young, when Mn homeostasis is not yet developed, increased Mn intake might pose a neurotoxic risk. Our work aimed at collecting new data on Mn accumulation during the perinatal period by using an experimental rat model in pups whose mothers were exposed orally to Mn in drink (as manganese chloride; dose of 2000 ppm Mn) throughout pregnancy and 11 days of lactation. Pups were cross-fostered at birth and placental and mammary transfer of Mn at birth and at the age of 11 days was evaluated. The total pup body burden of Mn was analysed by atomic absorption spectrometry. Concentrations of iron (Fe), zinc (Zn) and calcium (Ca) also were analysed at the end of the experiment.The concentration of Mn in perinatally exposed pups was 6-8 times higher than in controls, irrespective of the period and duration of exposure. After cessation of exposure, the Mn concentration decreased almost to control levels. Concentrations of other essential elements (Fe, Zn, Ca) were not affected by Mn exposure. Our results indicate the existence of an accurate regulation of Mn accumulation in pups exposed to Mn during the perinatal period. Copyright (c) 2005 John Wiley & Sons, Ltd.
机译：新生儿中与锰（Mn）相关的不良反应的风险已成为几项研究的主题，因为在配方奶喂养的婴儿中，锰的摄入量远高于母乳喂养的婴儿。在年轻人中，当尚未形成锰稳态时，锰摄入量增加可能会引起神经毒性。我们的工作旨在通过使用实验大鼠模型收集幼仔在围产期中的锰积累的新数据，这些幼仔的母亲在整个怀孕和哺乳期的第11天，口服饮料中的锰（作为氯化锰;剂量为2000 ppm Mn）。幼仔在出生时和胎盘中被交叉寄养，并在出生时和11天时对Mn的乳腺转移进行评估。通过原子吸收光谱法分析了锰的总幼体负担。在实验结束时还分析了铁（Fe），锌（Zn）和钙（Ca）的浓度。围产期暴露的幼仔中Mn的浓度比对照组高6-8倍，而不论持续时间和持续时间如何曝光。停止接触后，锰浓度几乎降低到控制水平。其他必需元素（铁，锌，钙）的浓度不受锰暴露的影响。我们的结果表明，围产期暴露于Mn的幼犬中存在Mn积累的精确调节。版权所有（c）2005 John Wiley＆Sons，Ltd.

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