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首页> 外文期刊>Journal of applied toxicology >Changes in serum alpha(2u)-globulin levels in castrated male rats treated with testosterone propionate in a Hershberger assay.
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Changes in serum alpha(2u)-globulin levels in castrated male rats treated with testosterone propionate in a Hershberger assay.

机译：在Hershberger分析中，用丙酸睾丸酮治疗的去势雄性大鼠的血清α（2u）-球蛋白水平变化。

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The Hershberger assay has been proposed as a candidate screening test method for the detection of androgenic and anti-androgenic chemicals and is being validated presently under the test guideline programme of the Organization for Economic Cooperation and Development (OECD). Rat alpha(2u)-globulin is male rat-specic protein appearing in their serum and urine, and the protein is known to be induced by androgens. We investigated the usefulness of measuring serum alpha(2u)-globulin levels as a parameter for the androgenic activity of chemicals tested in the Hershberger assay. The serum alpha(2u)-globulin level was measured after the administration of testosterone propionate at dosages of 0, 20, 100 or 500 microg kg(-1) day(-1) for ten consecutive days in the castrated male rats. The ventral prostate, balbocavernosus[sol ]levator ani muscles, glans penis and Cowper's gland were collected and weighed. Although all the androgen-responsive organ weights were increased signicantly at dosages of 100 and 500 microg kg(-1) day(-1), the serum alpha(2u)-globulin level was increased signicantly only at a dosage of 500 microg kg(-1) day(-1). These results show that the serum alpha(2u)-globulin level may be a useful biomarker for detecting androgenic activity caused by test chemicals, but it is less sensitive than the organ weights of androgen-responsive tissues in the Hershberger assay. Copyright (c) 2005 John Wiley & Sons, Ltd.
机译：Hershberger分析法已被提议作为检测雄激素和抗雄激素化学物质的候选筛选试验方法，目前正在经济合作与发展组织（OECD）的试验指南计划中得到验证。大鼠alpha（2u）-球蛋白是出现在其血清和尿液中的雄性大鼠特异性蛋白，已知该蛋白是由雄激素诱导的。我们调查了测量血清α（2u）-球蛋白水平作为在Hershberger分析中测试的化学物质的雄激素活性参数的有用性。在去势雄性大鼠中连续十天以0、20、100或500 microg kg（-1）day（-1）的剂量施用丙酸睾丸激素后，测量血清α（2u）-球蛋白水平。收集腹侧前列腺，balbocavernosus [肛提肌]，龟头龟头和考伯氏腺并称重。尽管在100和500 microg kg（-1）day（-1）的剂量下所有雄激素反应器官的重量均显着增加，但仅在500 microg kg（-1）的剂量下血清α（2u）-球蛋白水平才显着增加。 -1）天（-1）。这些结果表明，血清α（2u）-球蛋白水平可能是检测受试化学物质引起的雄激素活性的有用生物标志物，但它比Hershberger分析中的雄激素反应性组织的器官重量敏感度低。版权所有（c）2005 John Wiley＆Sons，Ltd.

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