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首页> 外文期刊>Journal of applied toxicology >Recent knowledge: Concepts of dermal absorption in relation to skin decontamination
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Recent knowledge: Concepts of dermal absorption in relation to skin decontamination

机译：最新知识：与皮肤净化有关的真皮吸收的概念

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Skin decontamination is an important step mitigating percutaneous absorption through the stratum corneum (SC), which is also a highly complex process. Thus, understanding diffusion mechanisms and measuring dermal absorption rates are critical to protect humans from toxic exposures. Here, highly varied literature is placed in a biological and clinical perspective in regards to decontamination. Literature from PubMed and Surge Laboratory library files were searched and reviewed for relevance. Recent data have shown multiple layers of SC structural heterogeneity, which results in unique substance partitioning characteristics across the membrane. As such, attempts to model and understand this behavior in alternative in vitro membranes prove difficult. More synthetic and natural membranes are being explored as models for in vivo behavior. In addition, commonly accepted decontamination methods are undergoing risk assessment. These recent and varied literature findings update available knowledge regarding skin decontamination and its challenges, with a focus on dermal absorption. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：皮肤净化是减轻皮肤通过角质层（SC）吸收的重要步骤，这也是一个非常复杂的过程。因此，了解扩散机制和测量皮肤吸收率对于保护人类免受毒性暴露至关重要。在这里，关于去污的生物学和临床观点各不相同。搜索PubMed和Surge Laboratory图书馆文件中的文献并进行相关性审查。最近的数据显示了SC结构异质性的多层结构，这导致整个膜具有独特的物质分配特性。因此，尝试模拟和了解替代体外膜中的这种行为非常困难。人们正在探索更多的合成和天然膜作为体内行为的模型。另外，普遍接受的去污方法正在接受风险评估。这些最近和各种各样的文献发现更新了有关皮肤去污及其挑战的可用知识，重点是皮肤吸收。版权所有（c）2015 John Wiley＆Sons，Ltd.

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