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首页> 外文期刊>Journal of applied toxicology >Selective vulnerability to kainate-induced oxidative damage in different rat brain regions.
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Selective vulnerability to kainate-induced oxidative damage in different rat brain regions.

机译：在不同大鼠脑区域中对海藻酸盐诱导的氧化损伤的选择性脆弱性。

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摘要

Some markers of oxidative injury were measured in different rat brain areas (hippocampus, cerebral cortex, striatum, hypothalamus, amygdala/piriform cortex and cerebellum) after the systemic administration of an excitotoxic dose of kainic acid (KA, 9 mg kg(-1) i.p.) at two different sampling times (24 and 48 h). Kainic acid was able to lower markedly (P < 0.05) the glutathione (GSH) levels in hippocampus, cerebellum and amygdala/piriform cortex (maximal reduction at 24 h). In a similar way, lipid peroxidation, as assessed by malonaldehyde and 4-hydroxyalkenal levels, significantly increased (P < 0.05) in hippocampus, cerebellum and amygdala/piriform cortex mainly at 24 h after KA. In addition, hippocampal superoxide dismutase (SOD) activity decreased significantly (P < 0.05) with respect to basal levels by 24 h after KA application. On the other hand, brain areas such as hypothalamus, striatum and cerebral cortex seem to be less susceptible to KA excitotoxicity. According to these findings, the pattern of oxidative injury induced by systemically administered KA seems to be highly region-specific. Further, our results have shown that a lower antioxidant status (GSH and SOD) seems not to play an important role in the selective vulnerability of certain brain regions because it correlates poorly with increases in markers of oxidative damage.
机译：在全身性给予兴奋性剂量的海藻酸（KA，9 mg kg（-1） ip）在两个不同的采样时间（24和48小时）。海藻酸能够显着降低（P <0.05）海马，小脑和杏仁核/梨状皮质中的谷胱甘肽（GSH）水平（24小时最大降低）。以类似的方式，脂质过氧化（通过丙二醛和4-羟基烯醛水平评估）主要在KA后24 h在海马，小脑和杏仁核/梨状皮质中显着增加（P <0.05）。此外，KA施用后24小时，海马超氧化物歧化酶（SOD）活性相对于基础水平显着降低（P <0.05）。另一方面，下丘脑，纹状体和大脑皮层等大脑区域似乎对KA兴奋性毒性较不敏感。根据这些发现，全身性施用KA引起的氧化损伤的模式似乎是高度区域特异性的。此外，我们的结果表明，较低的抗氧化剂状态（GSH和SOD）似乎在某些大脑区域的选择性脆弱性中不发挥重要作用，因为它与氧化损伤标记物的增加相关性很弱。

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