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首页> 外文期刊>Journal of applied toxicology >Cytokine fingerprinting and hazard assessment of chemical respiratory allergy.
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Cytokine fingerprinting and hazard assessment of chemical respiratory allergy.

机译：细胞因子指纹图谱和化学呼吸道过敏的危害评估。

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Allergic sensitization of the respiratory tract resulting in occupational asthma and other symptoms can be caused by a variety of chemicals and represents an important occupational health problem. Although there is a need to identify and characterize those chemicals that are able to cause respiratory allergy, there are currently no well validated or widely accepted predictive test methods. Some progress has been made with guinea pig assays, but our attention in this laboratory has focused instead on the development of novel approaches based on an understanding of the nature of immune responses induced in mice by chemical allergens. We have shown that whereas contact allergens provoke in mice selective type 1 immune responses, characterized by the secretion by draining lymph node cells (LNC) of high levels of the cytokine interferon gamma (IFN-gamma), chemical respiratory allergens stimulate instead preferential type 2 responses associated with comparatively high levels of interleukins 4 and 10 (IL-4 and IL-10). The divergent immune responses provoked by different classes of chemical allergens, and the phenotypes of selective cytokine secretion that characterize such responses, form the basis of a novel method-cytokine fingerprinting--that permits chemicals that have the potential to cause respiratory allergy to be identified and distinguished from those that are associated primarily with contact sensitization. In this article the immunobiological basis for cytokine fingerprinting is considered and the development, evaluation and practical application of the assay are reviewed. Copyright 2001 John Wiley & Sons, Ltd.
机译：呼吸道的过敏性致敏导致职业性哮喘和其他症状可能由多种化学物质引起，并且代表了重要的职业健康问题。尽管有必要鉴定和表征那些能够引起呼吸道过敏的化学物质，但目前尚无公认的或公认的预测性测试方法。豚鼠试验已经取得了一些进展，但是我们在实验室中的注意力改为基于对化学过敏原在小鼠中诱导的免疫应答性质的了解而致力于开发新方法。我们已经表明，接触性过敏原在小鼠中引起选择性的1型免疫反应，其特征是通过排泄淋巴结细胞（LNC）分泌高水平的细胞因子干扰素（IFN-γ），而化学呼吸道过敏原反而刺激了优先2型与较高水平的白介素4和10（IL-4和IL-10）相关的反应。不同类别的化学过敏原引起的不同免疫反应，以及表征这种反应的选择性细胞因子分泌表型，构成了一种新的方法，即细胞因子指纹图谱，这种方法可以鉴定出可能引起呼吸道过敏的化学物质。并区别于那些主要与接触敏化有关的事物。本文考虑了细胞因子指纹图谱的免疫生物学基础，并综述了该方法的开发，评估和实际应用。版权所有2001 John Wiley＆Sons，Ltd.

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