...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >Comparative in vitro toxicity of cadmium and lead on redox cycling in type II pneumocytes.
【24h】

Comparative in vitro toxicity of cadmium and lead on redox cycling in type II pneumocytes.

机译：镉和铅对II型肺细胞氧化还原循环的体外毒性比较。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Both cadmium and lead have pulmonary toxicity: cadmium can cause lung cancer, fibrosis and emphysema; lead can induce a moderate interstitial pulmonary fibrosis. Both metals give rise to depletion of glutathione and depletion of the protein-bound sulfhydryl groups, and lead to the production of reactive oxygen species. In the primary culture of type II pneumocytes, which is one of the most important cell groups from the aspect of glutathione metabolism and thus redox balance, the effect of cadmium chloride and lead nitrate upon the enzymes of the glutathione cycle, upon superoxide dismutase and upon the structure of type II pneumocytes was examined. Depending on the concentration, cadmium inhibited each of these parameters, whereas lead nitrate significantly increased the activity of glutathione reductase while inhibiting other parameters. Both metals induced damage of the membranes of type II cells, depending on the concentration, although cadmium caused significantly more damage than lead. The data obtained suggest that both substances cause an imbalance in the redox cycle and diversely affect the function and membrane structure of type II pneumocytes.
机译：镉和铅均具有肺毒性：镉可引起肺癌，纤维化和肺气肿;铅可诱发中度间质性肺纤维化。两种金属都会导致谷胱甘肽的消耗和与蛋白质结合的巯基的消耗，并导致产生活性氧。在II型肺细胞的原代培养中，这是从谷胱甘肽代谢和氧化还原平衡方面最重要的细胞群之一，氯化镉和硝酸铅对谷胱甘肽循环酶，超氧化物歧化酶和检查II型肺细胞的结构。取决于浓度，镉会抑制所有这些参数，而硝酸铅会显着增加谷胱甘肽还原酶的活性，同时会抑制其他参数。两种金属都会引起II型细胞膜的损伤，具体取决于浓度，尽管镉比铅引起的损伤要大得多。获得的数据表明，这两种物质均导致氧化还原循环失衡，并不同程度地影响II型肺细胞的功能和膜结构。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号