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首页> 外文期刊>Journal of applied toxicology >Historical control data on urinary and renal tissue biomarkers in naive male Wistar rats.
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Historical control data on urinary and renal tissue biomarkers in naive male Wistar rats.

机译：幼稚雄性Wistar大鼠尿和肾组织生物标志物的历史对照数据。

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摘要

Total proteins, angiotensin-converting enzyme, N-acetyl-beta-D-glucosaminidase, glutamine transaminase K and glutamine synthetase were determined in urine collected overnight (14 h: 6:00 p.m.-8:00 a.m.) from naive male Wistar rats; glutamine transaminase K and glutamine synthetase in the kidney 10,000 g supernatant and p-aminohippurate uptake in renal cortical slices also were measured. Urinary parameters were related both to urinary creatinine concentration and urinary flow rate; kidney parameters were related to protein concentration (enzymes) or slice/medium (S/M) ratio (p-aminohippurate uptake). The following reference ranges (1.0 and 99.0 percentiles) were obtained: urine: total urinary proteins (195 samples) 0.03-0.29 g mmol(-1) creatinine and 0.13-1.77 mg h(-1); angiotensin-converting enzyme (115 samples) 8.9-63.7 micromol mmol(-1) creatinine and 59.4-282.7 nmol h(-1); glutamine transaminase K (115 samples) 0-1.7 micromol mmol(-1) creatinine and 0-8.5 nmol h(-1); N-acetyl-beta-D-glucosaminidase (72 samples) 0.7-5.0 micromol mmol(-1) creatinine and 4.9-28.4 nmol h(-1) (naive male rats did not excrete glutamine synthetase); kidney: glutamine transaminase K (36 samples) 14.5-32.8 nmol mg(-1) protein; glutamine synthetase (22 samples) 13.9-48.6 nmol mg(-1) protein and p-aminohippurate (54 samples) 4.77-17.89 S/M. Urinary creatinine (r = -0.780), total urinary proteins (r = -0.521), angiotensin-converting enzyme (r = -0.650) and N-acetyl-beta-D-glucosaminidase (r = -0.796) but not glutamine transaminase K were well correlated with diuresis. In addition, the same parameters, but not glutamine transaminase K, were well correlated with creatinine (r = 0.604,0.701 and 0.747, respectively). Significant correlation also was observed between urinary indices adjusted to creatinine or urinary flow rate (total urinary proteins: r = 0.813; angiotensin-converting enzyme: r = 0.677; glutamine transaminase K: r = 0.939; N-acetyl-beta-D-glucosaminidase: r = 0.657). Finally, a low but significant correlation was found between total urinary proteins and angiotensin-converting enzyme (r = 0.293) and N-acetyl-beta-D-glucosaminidase (r = 0.471).
机译：确定了从幼稚的雄性Wistar大鼠过夜收集的尿液中的总蛋白，血管紧张素转化酶，N-乙酰基-β-D-氨基葡萄糖苷酶，谷氨酰胺转氨酶K和谷氨酰胺合成酶的过夜（14小时：下午6：00-下午8:00）。还测量了肾脏10,000 g上清液中的谷氨酰胺转氨酶K和谷氨酰胺合成酶，以及在肾皮质切片中摄取了p-氨基马尿酸盐。尿参数与尿肌酐浓度和尿流率有关。肾脏参数与蛋白质浓度（酶）或切片/培养基（S / M）比（对氨基马尿酸盐摄取）有关。获得以下参考范围（1.0和99.0个百分位数）：尿液：总尿蛋白（195个样品）0.03-0.29 g mmol（-1）肌酸酐和0.13-1.77 mg h（-1）;血管紧张素转换酶（115个样品）8.9-63.7 micromol mmol（-1）肌酸酐和59.4-282.7 nmol h（-1）;谷氨酰胺转氨酶K（115个样品）0-1.7 micromol mmol（-1）肌酐和0-8.5 nmol h（-1）; N-乙酰基-β-D-氨基葡萄糖苷酶（72个样品）0.7-5.0 micromol mmol（-1）肌酸酐和4.9-28.4 nmol h（-1）（幼稚的雄性大鼠未排泄谷氨酰胺合成酶）;肾脏：谷氨酰胺转氨酶K（36个样品）14.5-32.8 nmol mg（-1）蛋白;谷氨酰胺合成酶（22个样品）13.9-48.6 nmol mg（-1）蛋白和对氨基马尿酸盐（54个样品）4.77-17.89 S / M。尿肌酐（r = -0.780），总尿蛋白（r = -0.521），血管紧张素转化酶（r = -0.650）和N-乙酰基-β-D-氨基葡萄糖苷酶（r = -0.796），而不是谷氨酰胺转氨酶K与利尿有很好的相关性。此外，相同的参数（而不是谷氨酰胺转氨酶K）与肌酐具有很好的相关性（分别为r = 0.604、0.701和0.747）。在调整为肌酐或尿流率的尿指数之间也观察到显着相关性（总尿蛋白：r = 0.813;血管紧张素转化酶：r = 0.677;谷氨酰胺转氨酶K：r = 0.939; N-乙酰基-β-D-氨基葡萄糖苷酶：r ＝ 0.657）。最后，在总尿蛋白与血管紧张素转化酶（r = 0.293）和N-乙酰基-β-D-氨基葡萄糖苷酶（r = 0.471）之间发现了较低但显着的相关性。

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