...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >Psychometric functions for the olfactory and trigeminal detectability of butyl acetate and toluene.
【24h】

Psychometric functions for the olfactory and trigeminal detectability of butyl acetate and toluene.

机译：乙酸丁酯和甲苯的嗅觉和三叉神经可检测性的心理测量功能。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We measured psychometric (i.e. concentration-response) functions for the detection of odor, nasal pungency and eye irritation from butyl acetate and toluene. Olfactory detection was measured in subjects with normal olfaction (i.e. normosmics) for whom nasal trigeminal detection does not interfere because it requires much higher concentrations. Nasal trigeminal detection, called nasal pungency, was measured only in subjects lacking olfaction (i.e. anosmics) in order to avoid odor interference. Ocular trigeminal detection, called eye irritation, was measured in both groups. The method employed entailed a two-alternative, forced-choice procedure with presentation of increasing concentrations. The outcome showed, for both chemicals, similar ocular trigeminal chemosensitivity in normosmics and anosmics and similar overall ocular and nasal trigeminal chemosensitivity. Olfactory sensitivity was much higher than both forms of trigeminal sensitivity by concentration differences of six and four orders of magnitude for butyl acetate and toluene, respectively. Detectability plots (i.e. detection performance vs log concentration) for the three sensory endpoints followed an S-shaped function with a middle range section that showed a robust linear fit (r > 0.94) on graphs of z-score vs log concentration. These detectability functions allow the calculation of olfactory and trigeminal thresholds at various levels of performance. At a point half-way between random and perfect detection, trigeminal and olfactory threshold concentrations were, respectively, 0.67 (+/-0.32) and 2.28 (+/-1.77) log units lower than those measured by us in the past for the same chemicals using an analogous procedure but under just one, fixed, level of performance. The available data suggest that, although considerably laborious, detectability functions provide chemosensory thresholds of closer relevance to environmentally realistic conditions (e.g. whole-body exposures).
机译：我们测量了心理测量（即浓度响应）功能，以检测乙酸丁酯和甲苯的气味，鼻腔刺激性和眼睛刺激性。嗅觉检测是在嗅觉正常（即正常人群）的受试者中进行的，这些受试者的鼻三叉神经检测不受干扰，因为它需要更高的浓度。为了避免气味干扰，仅在缺乏嗅觉（即厌氧症）的受试者中进行了称为鼻刺激的鼻三叉检测。两组均进行了三眼三眼检测，称为眼刺激。所采用的方法伴随着浓度增加而进行的两种选择，强制选择程序。结果表明，对于两种化学药品，正常和厌氧症患者的三叉神经化学敏感性相似，总体的眼和鼻三叉神经化学敏感性相似。由于乙酸丁酯和甲苯的浓度差分别为六个和四个数量级，因此嗅觉敏感性远高于两种形式的三叉神经敏感性。三个感官端点的可检测性图（即检测性能与对数浓度）遵循S形函数，具有中间范围部分，在Z分数与对数浓度图上显示出稳健的线性拟合（r> 0.94）。这些可检测功能允许在各种性能级别上计算嗅觉和三叉阈值。在随机检测与完美检测之间的某个时间点，三叉神经和嗅觉阈浓度分别比我们过去在相同检测条件下测得的对数浓度低0.67（+/- 0.32）和2.28（+/- 1.77）个对数单位。化学品使用类似的程序，但仅在一个固定的性能水平下进行。现有数据表明，尽管相当费力，但可检测功能提供了与环境现实条件（例如全身暴露）密切相关的化学感应阈值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号