首页> 外文期刊>Journal of applied toxicology >Ultrastructural examination of rabbit aortic wall following high-fat diet feeding and selenium supplementation: a transmission electron microscopy study.
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Ultrastructural examination of rabbit aortic wall following high-fat diet feeding and selenium supplementation: a transmission electron microscopy study.

机译:高脂饮食喂养和补充硒后兔主动脉壁的超微结构检查:透射电镜研究。

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Experiments were carried out to examine the changes occurring in the wall of rabbit aortae following high-fat diet (HFD) feeding as well as HFD + selenium supplementation. Male New Zealand White rabbits were divided into three groups-control, HFD-fed and HFD + Se supplementation-and were treated for three months. The study depicted that levels of serum total cholesterol and triglycerides were markedly increased in the HFD-fed group as compared with control animals. However, in the HFD + Se-fed group, these levels were markedly suppressed vis-a-vis animals fed on HFD only. Development of atherogenic and atheromatic plaques has been shown at the light microscopy level in HFD-fed rabbits, whereas these developments were not visible in the HFD + Se-fed rabbits. Transmission electron microscopy findings indicated altered ultrastructure in the endothelial cells of the intimal layer as well as smooth-muscle cells of the medial layer in HFD-fed animals. However, these findings indicated normal ultrastructure in most of the cells, with little ultrastructural alterations from animals supplemented with Se along with HFD feeding. The study on the whole depicted the ability of Se to inhibit the onset of progression of aortic disease and hence has relevance to its therapeutic potential.
机译:进行实验以检查高脂饮食(HFD)以及HFD +硒补充后兔主动脉壁的变化。将雄性新西兰白兔分为三组:对照组,HFD喂养和HFD + Se补充,治疗三个月。该研究表明,与对照组相比,HFD喂养组的血清总胆固醇和甘油三酸酯水平显着增加。但是,在HFD +硒喂养的组中,与仅饲喂HFD的动物相比,这些水平明显受到抑制。在HFD喂养的兔子中,光学显微镜下已显示出粥样斑块和动脉粥样斑块的发展,而在HFD + Se喂养的兔子中看不到这些发展。透射电子显微镜的发现表明,在HFD喂养的动物中,内膜层内皮细胞​​和内侧层平滑肌细胞的超微结构发生了变化。然而,这些发现表明大多数细胞中的超微结构正常,补充了Se和HFD喂养的动物几乎没有超微结构改变。总体研究表明,硒具有抑制主动脉疾病进展的能力,因此与其治疗潜力有关。

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