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首页> 外文期刊>Journal of applied toxicology >Protective effects of quercetin on ultraviolet A light-induced oxidative stress in the blood of rat.
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Protective effects of quercetin on ultraviolet A light-induced oxidative stress in the blood of rat.

机译：槲皮素对紫外线引起的大鼠血液中氧化应激的保护作用。

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The oxidative effects of ultraviolet A (UVA) light (320-400 nm) and the antioxidant effects of quercetin were examined in rat blood.For this purpose, rats were divided into three groups: control, ultraviolet (UV) and ultraviolet + quercetin (UV + Q). The UV and UV + Q groups were irradiated for 4 h a day with UVA light (1.25 mW cm(2)) during periods of 3, 6 and 9 days. Quercetin (50 mg kg(-1) body wt.) was administered intraperitoneally in the UV + Q group rats before irradiation periods. Blood was taken 3, 6 and 9 days post-treatment.Plasma malondialdehyde (MDA) levels significantly increased after 9 days of daily exposure to UVA. Whole blood glutathione (GSH) levels significantly declined after 3-9 days of irradiation. Glutathione peroxidase activity on days 6 and 9 and glutathione reductase activities on days 3, 6 and 9 post-irradiation were diminished significantly. Superoxide dismutase and catalase activities decreased significantly 3-9 days post-irradiation.The administration of quercetin before the 9-day period of irradiation significantly reduced the increase in plasma MDA value. Whole blood GSH levels significantly decreased with the administration of quercetin on all days. Quercetin significantly increased antioxidant enzymes diminished by UVA irradiation.Exposure of rats to UVA light leads to oxidative stress, reflected by increased MDA and reduced antioxidant enzyme levels. The administration of quercetin appears to be a useful approach to reduce the damage produced by UVA radiation.
机译：检查大鼠血液中紫外线A（UVA）光（320-400 nm）的氧化作用和槲皮素的抗氧化作用，为此，将大鼠分为三组：对照组，紫外线（UV）和紫外线+槲皮素（ UV + Q）。在3、6和9天的时间内，每天用UVA光（1.25 mW cm（2））照射UV和UV + Q组4 h。在辐照期之前，在UV + Q组大鼠中腹膜内注射槲皮素（50 mg kg（-1）体重）。治疗后第3、6和9天采血。每天接触UVA 9天后血浆丙二醛（MDA）水平显着增加。辐射3-9天后，全血谷胱甘肽（GSH）水平显着下降。辐照后第6和9天的谷胱甘肽过氧化物酶活性和第3、6和9天的谷胱甘肽还原酶活性显着降低。辐照后3-9天超氧化物歧化酶和过氧化氢酶活性显着下降。辐照9天之前服用槲皮素显着降低了血浆MDA值的增加。全天服用槲皮素会导致全血GSH水平显着下降。槲皮素可显着增加被UVA辐射减弱的抗氧化酶。大鼠暴露于UVA光线会导致氧化应激，这可通过MDA升高和抗氧化酶水平降低来体现。槲皮素的给药似乎是减少UVA辐射产生的损害的有用方法。

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