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首页> 外文期刊>Journal of applied toxicology >A battery of DNA effect biomarkers to evaluate environmental exposure of Flemish adolescents.
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A battery of DNA effect biomarkers to evaluate environmental exposure of Flemish adolescents.

机译：一系列DNA效应生物标记物，用于评估佛拉芒青少年的环境暴露。

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The present paper deals with the evaluation of a battery of genotoxicity biomarkers in healthy Flemish adolescents and their relation with common pollutants occurring in their life environment. DNA damage as reflected by the comet assay appeared to be most sensitive to ozone (partial r(2) = 0.102, p < 0.00001), and to a lesser extent to ortho-cresol (partial r(2) 0.055; p 0.031; p = 0.013). 8-hydroxy-deoxyguanosine (8-OHdG) was only related to ortho-cresol (r(2) = 0.069; p < 0.007). Interestingly, the comet assay results and urinary 8-OHdG concentrations were positively correlated with a Pearson r = 0.21 (p = 0.003, N = 200). Logistic regression models revealed significant relations between chromatid breaks and 1-OH-pyrene (relative risk (RR): 1.58; p = 0.008), and t,t-muconic acid (RR: 1.71; p = 0.014). There was no correlation between micronucleus formation or occurrence of chromosomal or chromatid breaks on the one hand and comet or 8-OHdG results on the other hand. Thus, in this study the comet assay on whole blood samples and urine 8-OHdG measurements especially appeared sensitive biomarkers for assessing the genetic effects of environmental pollutants to which adolescents may be exposed.
机译：本文探讨了健康佛兰德青少年的遗传毒性生物标志物的评估及其与生活环境中常见污染物的关系。彗星试验所反映的DNA损伤似乎对臭氧最敏感（部分r（2）= 0.102，p <0.00001），对邻甲酚的影响较小（部分r（2）0.055; p 0.031; p = 0.013）。 8-羟基-脱氧鸟苷（8-OHdG）仅与邻甲酚有关（r（2）= 0.069; p <0.007）。有趣的是，彗星检测结果和尿中的8-OHdG浓度与Pearson r = 0.21（p = 0.003，N = 200）正相关。 Logistic回归模型显示染色单体断裂与1-OH-re之间的显着关系（相对风险（RR）：1.58; p = 0.008）和t，t-粘康酸（RR：1.71; p = 0.014）。一方面，微核形成与染色体或染色单体断裂的发生没有关系，另一方面，彗星或8-OHdG的结果之间没有相关性。因此，在这项研究中，对全血样本和尿液中的8-OHdG进行彗星测定特别是出现了敏感的生物标志物，用于评估可能暴露于青少年的环境污染物的遗传效应。

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