...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >Approach to estimation of absorption of aliphatic hydrocarbons diffusing from interior materials in an automobile cabin by inhalation toxicokinetic analysis in rats.
【24h】

Approach to estimation of absorption of aliphatic hydrocarbons diffusing from interior materials in an automobile cabin by inhalation toxicokinetic analysis in rats.

机译：通过大鼠吸入毒性动力学分析估算汽车车厢内部材料扩散的脂肪烃的吸收的方法。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The interior air of an automobile cabin has been demonstrated in our previous studies to be contaminated by high concentrations of a large variety of aliphatic hydrocarbons diffusing from the interior materials. In the present study, the amounts of seven selected aliphatic hydrocarbons absorbed by the car driver were estimated by evaluating their inhalation toxicokinetics in rats. Measured amounts of the substances were injected into a closed chamber system in which a rat had been placed, and the concentration changes in the chamber were examined. The toxicokinetics of the substances were evaluated based on concentration-time courses using a nonlinear compartment model. Their absorption amounts in humans at the levels of actual concentrations in the cabins without ventilation were extrapolated from the results found with the rats. The absorption amounts estimated for a driver during a 2 h drive were as follows: 6 microg/60 kg of human body weight for methylcyclopentane (interior concentration 23 microg/m(3) as median value in previous study), 5 microg for 2-methylpentane (36 microg/m(3)), 13 microg for n-hexane (65 microg/m(3)), 51 microg for n-heptane (150 microg/m(3)), 26 microg for 2,4-dimethylheptane (97 microg/m(3)), 17 microg for n-nonane (25 microg/m(3)) and 49 microg for n-decane (68 microg/m(3)). An inverse relationship was found between the exposure and absorption among the substances (e.g. between n-decane and 2,4-dimethylheptane). These findings suggest that not only the exposure concentrations but also the absorption amounts should be taken into account to evaluate the health effects of exposure to low concentrations of volatile compounds as environmental contaminants.
机译：在我们先前的研究中，汽车车厢的内部空气已被高浓度从内部材料中扩散出来的各种脂肪族烃污染。在本研究中，汽车驾驶员通过评估其在大鼠中的吸入毒代动力学来估算其吸收的7种选定脂肪族烃的量。将测定量的物质注入封闭的腔室系统中，在该系统中放置了老鼠，并检查了腔室内的浓度变化。使用非线性隔室模型，根据浓度-时间过程评估了物质的毒物动力学。从在老鼠身上发现的结果推断出它们在人体中在不通风的舱内实际浓度水平上的吸收量。驾驶员在2小时的驾驶过程中估计的吸收量如下：甲基环戊烷为6微克/ 60千克人体重量（内部研究中的内部浓度为23微克/立方米（3）为先前研究的中值），2-为5微克。甲基戊烷（36微克/米（3）），正己烷13微克（65微克/米（3）），正庚烷51微克（150微克/米（3）），2,4-微克26微克二甲基庚烷（97 microg / m（3）），正壬烷17 microg（25 microg / m（3））和正癸烷49 microg（68 microg / m（3））。发现物质之间的暴露和吸收之间存在反比关系（例如，正癸烷和2,4-二甲基庚烷之间）。这些发现表明，不仅应考虑暴露浓度，而且还应考虑吸收量，以评估暴露于低浓度挥发性化合物作为环境污染物的健康影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号