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首页> 外文期刊>Journal of applied toxicology >Exposure of Rana ridibunda to lead I. Study of lead accumulation in various tissues and hepatic delta-aminolevulinic acid dehydratase activity.
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Exposure of Rana ridibunda to lead I. Study of lead accumulation in various tissues and hepatic delta-aminolevulinic acid dehydratase activity.

机译：Rana ridibunda暴露于铅I.研究铅在各种组织中的积累和肝δ-氨基乙酰丙酸脱水酶的活性。

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摘要

There are few data at present on the impact of lead (Pb) on amphibians, although declines in amphibian populations due to man-made changes in the environment have been recorded in recent years. The impact of Pb in adult frogs, Rana ridibunda, was therefore examined. Animals were exposed to 14 mg l(-1) (ppm) aqueous Pb [as Pb(NO3)2] for 4, 10 and 30 days. The chosen Pb concentration corresponded to one-tenth of the 96-h LC50 value for Pb (138.18 ppm). We measured the Pb content of the liver, kidneys, ventral skin and gastrointestinal (GI) tract, and the activity of hepatic delta-aminolevulinic acid dehydratase (delta-ALA-D). Gross morphological characteristics of the frogs were not affected by Pb accumulation in their tissues. At the end of the 30 days of exposure all tissues accumulated Pb. The accumulation of Pb in the liver, kidneys and ventral skin was correlated positively with the time of exposure. The Pb concentration in the GI tract reached a plateau at day 10 and there was no significant increase of Pb in the liver after day 10, suggesting excretion of Pb. The activity of hepatic delta-ALA-D decreased by 90% on day 30 compared to control values. The decrease of hepatic delta-ALA-D activity was correlated negatively with the concentration of Pb in liver and the time of exposure. This study suggests that the hepatic delta-ALA-D activity can be used as a biomarker of Pb intoxication for this species.
机译：关于铅对两栖动物的影响的数据目前很少，尽管近年来记录到由于人为环境变化导致的两栖动物数量下降。因此，研究了铅对成年蛙蛙蛙的影响。使动物暴露于14 mg l（-1）（ppm）的Pb水溶液[作为Pb（NO3）2]持续4、10和30天。所选的Pb浓度相当于Pb的96小时LC50值的十分之一（138.18 ppm）。我们测量了肝脏，肾脏，腹侧皮肤和胃肠道（GI）的Pb含量，以及肝δ-氨基乙酰丙酸脱水酶（δ-ALA-D）的活性。青蛙的总体形态特征不受铅在其组织中积累的影响。在暴露的30天结束时，所有组织都积累了Pb。铅在肝脏，肾脏和腹侧皮肤中的积累与暴露时间呈正相关。胃肠道中的Pb浓度在第10天达到平台期，第10天后肝脏中Pb没有明显增加，表明Pb排泄。与对照值相比，在第30天，肝δ-ALA-D的活性降低了90％。肝δ-ALA-D活性的降低与肝脏中Pb的浓度和暴露时间负相关。这项研究表明，肝δ-ALA-D活性可用作该物种铅中毒的生物标记。

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