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首页> 外文期刊>Journal of applied toxicology >Influence of the viscosity of iodixanol on medullary and cortical blood flow in the rat kidney: a potential cause of Nephrotoxicity.
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Influence of the viscosity of iodixanol on medullary and cortical blood flow in the rat kidney: a potential cause of Nephrotoxicity.

机译：碘克沙醇粘度对大鼠肾脏髓样和皮质血流的影响：肾毒性的潜在原因。

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摘要

The aim of the present study was to investigate the effects of four iodinated contrast media on cortical, inner medullary and outer medullary blood flow in the rat kidney by using laser-Doppler flowmetry. The high-osmolar contrast medium diatrizoate did not significantly modify medullary perfusion but moderately decreased the cortical blood flow when injected at a dose of 1600 mg iodine kg(-1). Similar effects were obtained with the low-osmolar contrast media ioxaglate and iobitridol. In contrast, the new iso-osmolar contrast medium iodixanol induced a dose-dependent reduction of perfusion in all regions tested. This effect was accompanied by concomitant hypotension. The reduction of inner medullary and cortical blood flow induced by iodixanol was partially alleviated by heating the solution prior to injection and subsequently reducing its viscosity. In the outer medulla, however, this procedure did not improve blood flow. These results suggest that lowering the viscosity may palliate the harmful effects of iodixanol on the inner medulla and cortex, but may not protect the outer medulla from hypoxic injury.
机译：本研究的目的是通过激光多普勒血流仪研究四种碘化造影剂对大鼠肾脏皮质，髓内和髓外血流的影响。高渗透压造影剂泛影素并没有显着改变髓质灌注，但以1600 mg碘kg（-1）的剂量注射时适度降低了皮层血流量。用低渗造影剂碘克沙酯和碘比多醇可获得类似的效果。相反，新的等渗造影剂碘克沙醇在所测试的所有区域均引起剂量依赖性的灌注减少。这种作用伴随着低血压。通过在注射前加热溶液并随后降低其粘度，部分缓解了由碘克沙醇引起的髓内和皮质血流的减少。然而，在延髓外层，这种方法并不能改善血液流动。这些结果表明，降低粘度可减轻碘克沙醇对内髓质和皮质的有害作用，但可能无法保护外髓质免受低氧损伤。

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