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首页> 外文期刊>Journal of applied toxicology >Hypothesis Prolactin is tumorigenic to human breast: dispelling the myth that prolactin-induced mammary tumors are rodent-specific
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Hypothesis Prolactin is tumorigenic to human breast: dispelling the myth that prolactin-induced mammary tumors are rodent-specific

机译：假设催乳激素对人的乳房有致瘤性：消除了由催乳素引起的乳腺肿瘤是啮齿动物特异性的神话

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摘要

ABSTRACT: The commonly held assumption that rodent mammary tumors resulting from elevated prolactin are species-specific, or not biologically relevant to humans, is incorrect. Substantial epidemiological, clinical, and biological evidence now exists confirming the role of prolactin in human breast cancer. This evidence is evaluated and the argument presented that the tumorigenic risk from prolactin is therefore not species-specific to rodents but directly applies to humans. Further, as the mechanisms of prolactin-induced mammary tumor promotion and development appear analogous between rodents and humans, mammary tumorigenic findings in rodent carcinogenicity bioassays are both predictive and biologically relevant to the human response. Toxicologists and regulators need to consider this in carcinogenicity risk assessments.
机译：摘要：普遍认为，由催乳激素升高引起的啮齿类乳腺肿瘤是物种特异性的，或者与人类生物学无关，这是不正确的。现在存在大量的流行病学，临床和生物学证据，证实了催乳素在人乳腺癌中的作用。对这一证据进行了评估，该论据提出，催乳激素的致瘤风险因此不是啮齿动物的物种特异性，而是直接适用于人类。此外，由于催乳素诱导的乳腺肿瘤的促进和发展的机制在啮齿动物和人类之间看起来相似，所以在啮齿动物致癌性生物测定中的乳腺致瘤发现既是预测性的，也是与人类反应生物学相关的。毒理学家和监管者在致癌性风险评估中需要考虑这一点。

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