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首页> 外文期刊>Journal of applied toxicology >Combinations of parabens at concentrations measured in human breast tissue can increase proliferation of MCF-7 human breast cancer cells
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Combinations of parabens at concentrations measured in human breast tissue can increase proliferation of MCF-7 human breast cancer cells

机译：在人的乳腺组织中检测到浓度的对羟基苯甲酸酯类组合可增加MCF-7人乳腺癌细胞的增殖

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摘要

The alkyl esters of p-hydroxybenzoic acid (parabens), which are used as preservatives in consumer products, possess oestrogenic activity and have been measured in human breast tissue. This has raised concerns for a potential involvement in the development of human breast cancer. In this paper, we have investigated the extent to which proliferation of MCF-7 human breast cancer cells can be increased by exposure to the five parabens either alone or in combination at concentrations as recently measured in 160 human breast tissue samples. Determination of no-observed-effect concentrations (NOEC), lowest-observed-effect concentrations (LOEC), EC50 and EC100 values for stimulation of proliferation of MCF-7 cells by five parabens revealed that 43/160 (27%) of the human breast tissue samples contained at least one paraben at a concentration ≥ LOEC and 64/160 (40%)NOEC. Proliferation of MCF-7 cells could be increased by combining all five parabens at concentrations down to the 50th percentile (median) values measured in the tissues. For the 22 tissue samples taken at the site of ER+PR+primary cancers, 12 contained a sufficient concentration of one or more paraben to stimulate proliferation of MCF-7 cells. This demonstrates that parabens, either alone or in combination, are present in human breast tissue at concentrations sufficient to stimulate the proliferation of MCF-7 cells in vitro, and that functional consequences of the presence of paraben in human breast tissue should be assessed on the basis of all five parabens and not single parabens individually.
机译：对羟基苯甲酸（对羟基苯甲酸酯）的烷基酯在消费产品中用作防腐剂，具有雌激素活性，已在人的乳房组织中进行了测定。这引起了对潜在参与人类乳腺癌发展的关注。在本文中，我们研究了通过在160例人体乳腺组织样本中单独或组合暴露于五种对羟基苯甲酸酯，可以增加MCF-7人体乳癌细胞的增殖程度。确定五种对羟基苯甲酸酯刺激MCF-7细胞增殖的未观察到的浓度（NOEC），最低观察到的浓度（LOEC），EC50和EC100值表明，有43/160（27％）的人类乳腺组织样品中至少含有一种对羟基苯甲酸酯，浓度≥LOEC，且64/160（40％）> NOEC。通过将所有五个对羟基苯甲酸酯的浓度降低到组织中测得的第50个百分位数（中值），可以增加MCF-7细胞的增殖。对于在ER + PR +原发癌部位采集的22个组织样本，其中12个含有足够浓度的一种或多种对羟基苯甲酸酯以刺激MCF-7细胞的增殖。这表明对羟基苯甲酸酯单独或组合存在于人的乳腺组织中，其浓度足以刺激体外MCF-7细胞的增殖，并且应评估对羟基苯甲酸酯在人乳腺组织中的功能后果。所有五个对羟基苯甲酸酯的基础，而不是单个对羟基苯甲酸酯。

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