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首页> 外文期刊>Journal of applied toxicology >Ninety days of repeated gavage administration of Rhodiola imbricata extract in rats
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Ninety days of repeated gavage administration of Rhodiola imbricata extract in rats

机译：大鼠反复强饲红景天提取物90天

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摘要

Rhodiola imbricata is a high-altitude plant, possesses adaptogenic, immunomodulatory, anti-oxidant and cytoprotective activity, and is widely used in traditional medicine. The present study was designed to ascertain the safety of aqueous extract of R. imbricata root when administered by gavage to rats for 90days. Four groups of animals, each consisting of 15 males and 15 females, were administered 0, 100, 250 or 500mgkg-1 extract, in a single dose per day. The experimental rats when administered 100mgkg-1 of extract did not show any significant change in their body weight gain, organ/body weight ratio, or histological, hematological and biochemical variables studied. However, at higher doses of 250 and 500mgkg-1 extract, an increase in the body weight of rats of both the sexes was apparent without any change in their organ/body weight ratio. Furthermore, a noteworthy increase in plasma glucose and protein levels was recorded at both the higher doses, which were restored to normal after a 2-week withdrawal of treatment. Based on the findings of this study, the no observed effect level was 100mgkg-1 body weight per day of aqueous root extract of R. imbricata in rats administered subchronically.
机译：锦红景天是一种高海拔植物，具有适应原性，免疫调节，抗氧化和细胞保护作用，广泛用于传统医学中。本研究旨在确定强饲法根茎水提物对大鼠灌胃90天时的安全性。每天给四组动物，分别由15只雄性和15只雌性组成，分别以0、100、250或500mgkg-1的提取物给药。给予100mgkg-1提取物的实验大鼠在体重增加，器官/体重比或所研究的组织学，血液学和生化变量方面未显示任何显着变化。然而，在250和500mgkg-1提取物的较高剂量下，两性大鼠的体重明显增加，而器官/体重比却没有任何变化。此外，在两个较高剂量下均记录到血浆葡萄糖和蛋白质水平显着增加，在停药2周后恢复正常。根据这项研究的发现，在亚慢性给药的大鼠中，未观察到的作用水平为每天100 mgkg-1体重的圆叶罗非鱼根提取物。

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