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首页> 外文期刊>Journal of applied toxicology >Influence of cadmium on metallothionein expression and products of lipid peroxidation in the organs of hares (Lepus europaeus Pallas)
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Influence of cadmium on metallothionein expression and products of lipid peroxidation in the organs of hares (Lepus europaeus Pallas)

机译：镉对野兔器官中金属硫蛋白表达和脂质过氧化产物的影响

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Cadmium occurs naturally in the environment and as an anthropogenic pollutant. Exposure to low concentrations of cadmium is inevitable and may produce toxic effects. Another important aspect of cadmium toxicity is its interaction, often antagonistic, with essential elements such as selenium. The aim of this study was to highlight the risks of long-term exposure to low cadmium concentrations, using a scientific and chemical approach and hares (Lepus europaeus Pallas) as model organisms in a field study. Two study areas were monitored. Levels of cadmium and selenium were quantified in the organs of hares, the expression of metallothioneins I + II and the products of lipid peroxidation were determined. The median cadmium concentrations (wet weight) in the muscle, liver, kidney and brain of hares from an exposed group ranged from 0.033 to 0.037, 0.763 to 1.054, 3.090 to 16.594 and 0.016 to 0.087μg g-1, respectively; whereas, the median selenium concentrations (wet weight) ranged from 0.100 to 0.108, 0.153 to 0.332, 0.677 to 0.701 and 0.078 to 0.116μg g-1, respectively. Expression of the metallothioneins I + II proteins was observed in tissues. Lipid peroxidation (LPO) levels, measured as malondialdehyde (MDA) equivalents, increased with the cadmium concentration. Further research on long-term exposure to low concentrations of cadmium in the environment is needed.
机译：镉自然存在于环境中并作为人为污染物。不可避免地要暴露于低浓度的镉中，并可能产生毒性作用。镉毒性的另一个重要方面是它与必需元素（如硒）的相互作用（通常是拮抗作用）。这项研究的目的是通过科学和化学方法和野兔（Lepus europaeus Pallas）作为野外研究的模型生物，强调长期暴露于低镉浓度下的风险。监测了两个研究区域。定量测定野兔器官中镉和硒的含量，测定金属硫蛋白I + II的表达以及脂质过氧化产物。暴露组兔子的肌肉，肝脏，肾脏和大脑中镉的中位数浓度（湿重）分别为0.033至0.037、0.763至1.054、3.090至16.594和0.016至0.087μgg-1。硒的中位浓度（湿重）分别为0.100至0.108、0.153至0.332、0.677至0.701和0.078至0.116μgg-1。在组织中观察到金属硫蛋白I + II蛋白的表达。脂质过氧化（LPO）水平以丙二醛（MDA）当量衡量，随镉浓度增加。需要对环境中长期暴露于低浓度镉的进一步研究。

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