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首页> 外文期刊>Journal of applied toxicology >Determination of the oestrogenic (uterotrophic) activity of extracts of 'general purpose polystyrene (GPPS)' using immature female rats.
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Determination of the oestrogenic (uterotrophic) activity of extracts of 'general purpose polystyrene (GPPS)' using immature female rats.

机译：使用未成熟雌性大鼠测定“通用聚苯乙烯（GPPS）”提取物的雌激素（滋养）活性。

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In Japan there is growing concern about the possible adverse effects of consumption of food from styrene containers (mainly those made from polystyrene paper) due to the alleged oestrogenic activity of styrene oligomers (dimers and trimers), which may migrate into the food. To examine the possible oestrogenic activity of styrene dimers and trimers, extracts were made from 'general purpose polystyrene (GPPS)' and administered orally to immature female rats over a 4 day period. Increase of uterus weight (wet and blotted) was used for assessment of possible oestrogenic activity. To establish the sensitivity of the test method, immature rats were treated with diethylstilboestrol (DES), a well-known oestrogenic compound. It was found that treatment of rats with levels of up to 60 microg of styrene dimers and 930 microg of styrene trimers per kilogram body weight per day did not give any statistically significant increase of the uterus weight (wet or blotted), whereas DES caused statistically significant, dose-related increases in uterus weight at levels as low as 0.89 microg kg(-1) body weight day(-1). It was concluded that, compared with the estimated maximum human daily intake of styrene trimers of 1 microg kg(-1) body weight day(-1) from polystyrene food containers, the risk of adverse human health effects with respect to oestrogenicity may be considered negligible. Copyright 2001 John Wiley & Sons, Ltd.
机译：在日本，人们越来越担心从苯乙烯容器（主要是由聚苯乙烯纸制成的容器）中食用食物可能产生的不利影响，原因是据称苯乙烯低聚物（二聚体和三聚体）的雌激素活性可能会迁移到食品中。为了检查苯乙烯二聚体和三聚体的可能的雌激素活性，从“通用聚苯乙烯（GPPS）”中提取提取物，并在4天的时间内口服给未成熟的雌性大鼠。子宫重量的增加（湿的和印迹的）用于评估可能的雌激素活性。为了确定测试方法的敏感性，未成熟的大鼠用众所周知的雌激素化合物二乙基雌二醇（DES）进行了治疗。研究发现，每天每公斤体重高达60微克的苯乙烯二聚体和930微克的苯乙烯三聚体水平的大鼠治疗，子宫重量（湿润或印迹）的统计学上没有显着增加，而DES统计学上引起在低至0.89 microg kg（-1）体重日（-1）的水平下，子宫重量的剂量相关显着增加。结论是，与估计的人类每天从聚苯乙烯食品容器中摄入的三聚苯乙烯三聚体的最大最大摄入量为1微克kg（-1）体重天（-1）相比，可以考虑人类对雌激素产生不利健康影响的风险微不足道。版权所有2001 John Wiley＆Sons，Ltd.

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