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首页> 外文期刊>Journal of applied toxicology >Effects of pond water, sediment and sediment extract samples from New Hampshire, USA on early Xenopus development and metamorphosis: comparison to native species.
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Effects of pond water, sediment and sediment extract samples from New Hampshire, USA on early Xenopus development and metamorphosis: comparison to native species.

机译：美国新罕布什尔州的池塘水，沉积物和沉积物提取物样品对非洲爪蟾早期发育和变态的影响：与本地物种的比较。

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In an effort to assess potential ecological hazards to amphibian species in selected regions within New Hampshire, the traditional Frog Embryo Teratogenesis Assay-Xenopus (FETAX), a 14-/21 day tail resorption thyroid disruption assay and >30 day limb development tests were conducted with representative surface water and sediment samples. Two separate sets of samples collected from five sites were evaluated. The primary objectives of the study were to determine if samples were capable of inducing early embryo-larval maldevelopment, to determine if maldevelopment included limb defects, to determine if thyroxine co-administration altered the rates of limb malformation and to evaluate the impact of the samples on growth rates, developmental progress and metamorphic climax. Results from these studies suggested that pond water and sediment extract samples, but not whole sediment samples, from B2, FW, LP and W ponds were capable of inducing abnormal early embryo-larval development. In addition, water samples from B2 and W ponds induced significant abnormal hindlimb development. Some abnormal forelimb development was noted in the tail resorption studies, but not to the same extent as the hindlimbs. Each of the water samples induced appreciable developmental delay, including the paired reference site B1, which could be reversed by the addition of exogenous thyroxine. Copyright 2001 John Wiley & Sons, Ltd.
机译：为了评估新罕布什尔州部分地区对两栖动物物种的潜在生态危害，进行了传统的蛙胚胎致畸试验-非洲爪蟾（FETAX），14- / 21天的尾巴吸收甲状腺破坏试验和> 30天的肢体发育测试具有代表性的地表水和沉积物样品。评价了从五个地点收集的两组独立的样品。该研究的主要目的是确定样品是否能够诱导早期胚胎-幼虫的发育不良，确定发育不良是否包括肢体缺损，确定甲状腺素联合给药是否改变了肢体畸形的发生率并评估样品的影响。增长率，发育进度和变态高潮。这些研究的结果表明，B2，FW，LP和W池塘的池塘水和沉积物提取物样本，而不是全部沉积物样本，能够诱导异常的早期幼虫发育。另外，来自B2和W池塘的水样引起明显的异常后肢发育。在尾巴吸收研究中发现了一些异常的前肢发育，但程度与后肢不同。每个水样都引起明显的发育延迟，包括配对的参考位点B1，可以通过添加外源甲状腺素来逆转。版权所有2001 John Wiley＆Sons，Ltd.

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