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首页> 外文期刊>Journal of applied toxicology >Effects of vitamin E on reactive oxygen species-mediated 2,3,7,8-tetrachlorodi-benzo-p-dioxin toxicity in rat testis.
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Effects of vitamin E on reactive oxygen species-mediated 2,3,7,8-tetrachlorodi-benzo-p-dioxin toxicity in rat testis.

机译：维生素E对大鼠睾丸中活性氧介导的2,3,7,8-四氯二苯并-对二恶英毒性的影响。

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This study was undertaken to investigate whether treatment with vitamin E protects rat testis from oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Male rats of Wistar strain were administered TCDD at doses of 1, 10 and 100 ng kg(-1) body wt. day(-1) for 45 days. Other groups of animals were co-administered TCDD (1, 10 and 100 ng kg(-1) body wt. day(-1)) and vitamin E (20 mg kg(-1) body wt. day(-1)) for 45 days. Animals administered TCDD and those co-administered TCDD and vitamin E did not show any significant change in body weight. Administration of TCDD decreased the weights of the testis, epididymis, seminal vesicles and ventral prostate. The daily sperm production decreased in the animals administered TCDD from the control values of 22.19 +/- 2.67 to 13.10 +/- 3.16 x 10(6). There was a significant decline in the activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase with concomitant increased levels of hydrogen peroxide and lipid peroxidation. Co-administration of TCDD and vitamin E did not show any significant changes in the weights of the testis, epididymis, seminal vesicles and ventral prostate. The daily sperm production remained unchanged in the animals co-administered TCDD and vitamin E. The activities of antioxidant enzymes and the levels of hydrogen peroxide and lipid peroxidation did not change in the animals co-administered TCDD and vitamin E. The results suggested that administration of TCDD induces oxidative stress in testis, and vitamin E could impart a protective effect against TCDD-induced oxidative stress.
机译：这项研究旨在调查维生素E处理是否能保护大鼠睾丸免受2,3,7,8-四氯二苯并-对二恶英（TCDD）诱导的氧化应激。 Wistar品系的雄性大鼠接受TCDD的剂量为1、10和100 ng kg（-1）体重。第（-1）天，共45天。其他组的动物同时服用TCDD（1、10和100 ng kg（-1）体重天（-1））和维生素E（20 mg kg（-1）体重天（-1））持续45天。服用TCDD的动物以及同时服用TCDD和维生素E的动物的体重没有任何明显变化。 TCDD的使用减少了睾丸，附睾，精囊和腹侧前列腺的重量。施用TCDD的动物的每日精子产量从对照组的22.19 +/- 2.67降低到13.10 +/- 3.16 x 10（6）。超氧化物歧化酶，过氧化氢酶，谷胱甘肽还原酶和谷胱甘肽过氧化物酶的活性显着下降，同时过氧化氢和脂质过氧化水平增加。 TCDD和维生素E的共同给药未显示睾丸，附睾，精囊和腹侧前列腺的重量有任何显着变化。并用TCDD和维生素E的动物的每日精子产量保持不变。并用TCDD和维生素E的动物的抗氧化酶活性，过氧化氢和脂质过氧化水平没有变化。 TCDD引起的睾丸氧化应激，维生素E可以抵抗TCDD引起的氧化应激。

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