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首页> 外文期刊>Journal of applied toxicology >Relevance of the developmental toxicity of ethanol in the occupational setting: a review.
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Relevance of the developmental toxicity of ethanol in the occupational setting: a review.

机译：在职业环境中乙醇发育毒性的相关性：综述。

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摘要

Numerous studies have been conducted investigating the reproductive toxicology of ethanol, the overwhelming majority concerning the adverse effects of consuming alcohol in beverages during pregnancy. Because many of the in vivo studies were designed to model alcoholism, they used comparatively high doses and assessed relatively few endpoints. Outcomes may have been affected by disturbances of metabolism at such high exposures, giving rise to secondary effects on development. The available data on ethanol from "conventional" developmental toxicity study test methods of the type used for regulatory hazard assessment of chemicals are limited. It is in this context, however, i.e. the use of ethanol as an industrial chemical rather than as a component of beverages, that this review is based. Using the usual criteria applied for the purpose of hazard assessment of industrial chemicals, it is concluded that there is no evidence that industrial exposure to ethanol is a developmental toxicity hazard. Developmental toxicity may result from drinking alcoholic beverages, the threshold level for all aspects of which has yet to be de fi ned. This is not, however, considered relevant to the low blood alcohol concentrations resulting from any conceivable inhalation or dermal exposure in the workplace or through the directed use of any consumer product containing ethanol.
机译：已经进行了许多研究，以研究乙醇的生殖毒理学，其中绝大多数涉及怀孕期间在饮料中饮用酒精的不利影响。由于许多体内研究旨在模拟酒精中毒，因此他们使用了相对较高的剂量并评估了相对较少的终点。在如此高的暴露水平下，结果可能受到新陈代谢紊乱的影响，从而对发育产生了次级影响。用于化学物质法规危险性评估的“常规”发育毒性研究测试方法中有关乙醇的可用数据有限。然而，本综述正是基于这种情况，即使用乙醇作为工业化学品而不是饮料的成分。使用用于评估工业化学品危害的常用标准，可以得出结论，没有证据表明工业暴露于乙醇是发育毒性危害。饮用酒精性饮料可能会导致发育毒性，目前尚不确定其所有方面的阈值水平。但是，这与在工作场所中任何可能的吸入或皮肤接触或通过直接使用任何含乙醇的消费品引起的低血液酒精浓度无关。

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