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首页> 外文期刊>Journal of applied toxicology >Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats.
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Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats.

机译：α-硫辛酸对氯喹诱导的大鼠肝毒性的保护作用。

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摘要

Oral administration of a-lipoic acid, a metavitamin, was investigated for its possible hepatoprotective effect in Wistar rats against chloroquine-induced toxicity. Rats were treated orally with alpha-lipoic acid (10, 30 and 100 mg x kg(-1) day(-1)) for 7 days before a single oral administration of chloroquine (970 mg x kg(-1) day(-1)) and alpha-lipoic acid treatment was continued for three more days. The increased level of serum enzymes (aspartate transaminase, alanine transaminase and alkaline phosphatase), bilirubin, lipids and plasma thiobarbituric acid-reactive substances (TBARS) and hydroperoxides observed in rats treated with chloroquine were very much reduced in rats treated with alpha-lipoic acid plus chloroquine. A significant decrease in plasma antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E were observed in chloroquine-treated rats when compared with control rats. Administration of alpha-lipoic acid significantly improved the levels of plasma antioxidants GSH, vitaminC and vitamin E in chloroquine-treated rats. In the case of 100 mg x kg(-1) day(-1) the effect was highly significant compared with the other doses (10 and 30 mg x kg(-1) day(-1)). The results of the study revealed that alpha-lipoic acid could offer protection against chloroquine-induced hepatotoxicity. alpha-Lipoic acid had a better protective effect when compared with silymarin, a reference drug.
机译：研究了口服α-硫辛酸（一种维生素）在Wistar大鼠中对氯喹诱导的毒性的肝保护作用。在单次口服氯喹（970 mg x kg（-1）天（-）之前，大鼠接受α-硫辛酸（10、30和100 mg x kg（-1）天（-1））口服治疗7天。 1））和α-硫辛酸处理继续进行三天。在用氯喹治疗的大鼠中观察到的血清酶（天冬氨酸转氨酶，丙氨酸转氨酶和碱性磷酸酶），胆红素，脂质和血浆硫代巴比妥酸反应性物质（TBARS）和氢过氧化物的水平升高大大降低。加氯喹。与对照大鼠相比，在用氯喹治疗的大鼠中观察到血浆抗氧化剂的显着减少，例如还原型谷胱甘肽（GSH），维生素C和维生素E的减少。给予α-硫辛酸可显着改善氯喹治疗大鼠的血浆抗氧化剂GSH，维生素C和维生素E的水平。在100 mg x kg（-1）day（-1）的情况下，该效果与其他剂量（10和30 mg x kg（-1）day（-1））相比非常显着。研究结果表明，α-硫辛酸可以提供针对氯喹诱导的肝毒性的保护作用。与参考药物水飞蓟素相比，α-硫辛酸具有更好的保护作用。

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