Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.

Curtin ML; Florjancic AS; Cohen J; Gu WZ; Frost DJ; Muchmore SW; Sham HL

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Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.

机译：蛋白质法呢基转移酶的新型和选择性含咪唑的联苯抑制剂。

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A series of imidazole-containing biphenyls was prepared and evaluated in vitro for inhibition of FTase and cellular Ras processing. Several of these analogues, such as 21, are potent inhibitors of FTase (<1nM), FTase/GGTase selective (>300-fold) and cellularly active (

机译：制备了一系列含咪唑的联苯，并在体外评估了对FTase的抑制和细胞Ras加工的能力。其中一些类似物（例如21）是FTase（<1nM），FTase / GGTase选择性（> 300倍）和细胞活性（

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《Bioorganic and Medicinal Chemistry Letters》 |2003年第7期|共5页
作者
Curtin ML; Florjancic AS; Cohen J; Gu WZ; Frost DJ; Muchmore SW; Sham HL;
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正文语种 eng
中图分类药学;生物化学;
关键词
inhibitors; Imidazoles; protein farnesyltransferase; diphenyl; structure; 咪唑类;

机译：inhibitors;Imidazoles;protein farnesyltransferase;diphenyl;structure;咪唑类;

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1. Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase. [J] . Curtin ML, Florjancic AS, Cohen J, Bioorganic and Medicinal Chemistry Letters . 2003,第7期

机译：蛋白质法呢基转移酶的新型和选择性含咪唑的联苯抑制剂。
2. Selective matrix metalloproteinase inhibitor, N-biphenyl sulfonyl phenylalanine hydroxamic acid, inhibits the migration of CD4(+) T lymphocytes in patients with HTLV-I-associated myelopathy. [J] . Ikegami M, Ikegami N, Osame M Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2002,第1a2期

机译：选择性基质金属蛋白酶抑制剂，N-联苯磺酰基苯丙氨酸异羟肟酸，抑制HTLV-I相关性脊髓病患者的CD4（+）T淋巴细胞迁移。
3. An Effective Antiviral Approach Targeting Hepatitis B Virus with NJK14047, a Novel and Selective Biphenyl Amide p38 Mitogen-Activated Protein Kinase Inhibitor [J] . Kim So-Young, Kim Hong, Kim Sang-Won, Antimicrobial agents and chemotherapy. . 2017,第8期

机译：靶向乙型肝炎病毒的有效抗病毒方法，具有NJK14047，一种新颖和选择性联苯酰胺P38丝烯基活性蛋白激酶抑制剂
4. The Effects of Go 6983 and a Selective Protein Kinase C beta II Peptide Inhibitor on Local Hyperglycemia-Indnced Leukocyte-Endothelial Interactions [C] . Qian Chen, Edward Iames, Daniel Torino American Peptide Symposium . 2011

机译：Go 6983和选择性蛋白激酶CβII肽抑制剂对局部高血糖 - indncia-Indcocyte-内皮相互作用的影响
5. Site -selective modification of proteins using protein farnesyltransferase. [D] . Duckworth, Benjamin P. 2007

机译：使用蛋白质法呢基转移酶对蛋白质进行位点选择性修饰。
6. An Effective Antiviral Approach Targeting Hepatitis B Virus with NJK14047 a Novel and Selective Biphenyl Amide p38 Mitogen-Activated Protein Kinase Inhibitor [O] . So-Young Kim, Hong Kim, Sang-Won Kim, 2017

机译：NJK14047新型和选择性的联苯酰胺p38丝裂原激活的蛋白激酶抑制剂NJK14047靶向乙型肝炎病毒的有效抗病毒方法。
7. Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. [O] . Hast, MA, Fletcher, S, Cummings, CG, 2009

机译：抗疟疾和抗癌乙二胺抑制剂与蛋白质法呢基转移酶结合和选择性的结构基础。

Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.

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