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首页> 外文期刊>Journal of athletic training >Intramuscular heating through Fluidotherapy and heat shock protein response
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Intramuscular heating through Fluidotherapy and heat shock protein response

机译：通过流体疗法进行肌肉内加热和热休克蛋白反应

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Context: Therapeutic modalities that can increase intramuscular temperature commonly are used to treat injuries in the clinical setting. Researchers recently have suggested that the physiologic changes occurring during an increase in temperature also could provide a cytoprotective effect for exerciseinduced muscle damage. Objective(s): To determine if the Fluidotherapy treatment increases the inducible expression of heat shock protein (HSP), to identify the rate of heating that occurs in the lower extremity with Fluidotherapy treatment, and to evaluate the relationship between the inducible expression of HSP and temperature. Design: Controlled laboratory study. Setting: Laboratory. Patients or Other Participants: Six male (age = 21.67 ± 1.63 years, height = 180.09 ± 4.83 cm, mass = 87.60 ± 10.51 kg) and ± female (age= 24.60 ± 4.59 years, height =151.05 ± 35.76 cm, mass = 55.59 ± 14.58 kg) college-aged students. Intervention(s): One lower extremity was randomly selected to receive the heat treatment, and the other extremity received no treatment. Main Outcome Measure(s): We measured intramuscular temperature every 10 minutes, determining peak intramuscular temperature by 2 identical sequential measurements, and we analyzed the time to peak temperature. We analyzed the amount of HSP70 expression and HSP27P:T (ratio of HSP27 to the total HSP27 expression) in the gastrocnemius and soleus muscles and measured baseline skinfold thickness and estradiol levels. Results: Fluidotherapy increased intramuscular temperature by 5.66 ± 0.788C (t11 = 25.67, P .001) compared with baseline temperature, with a peak temperature of 39.08°C ± 0.398C occurring at 84.17 ± 6.69 minutes. We did not find a heat treatment effect for HSP70 or HSP27P:T in the gastrocnemius or soleus muscles (P .05). Peak temperature and the percentage change of HSP70 were positively correlated for the gastrocnemius and soleus muscles (P .05). We found no other correlations for skinfold thickness, sex, or estradiol levels (P .05). No effect of sex for skinfold thickness or estradiol levels at baseline was discovered (P .05). Conclusions: This Fluidotherapy protocol increased the intramuscular temperature to a therapeutic level; however, it did not stimulate inducible HSP70 or HSP27P:T in the soleus and gastrocnemius muscles regardless of sex or skinfold thickness. These data confirmed that Fluidotherapy is an effective heating modality but suggested it is not an effective method for stimulating an HSP response in the lower limb.
机译：背景：通常可以增加肌内温度的治疗方法在临床环境中用于治疗损伤。研究人员最近提出，温度升高期间发生的生理变化也可能为运动引起的肌肉损伤提供细胞保护作用。目的：确定液体疗法是否会增加热休克蛋白（HSP）的诱导表达，确定使用液体疗法在下肢发生的升温速率，并评估HSP诱导表达之间的关系和温度。设计：对照实验室研究。地点：实验室。患者或其他参与者：六男（年龄= 21.67±1.63岁，身高= 180.09±4.83 cm，体重= 87.60±10.51 kg）和±女性（年龄= 24.60±4.59岁，身高= 151.05±35.76 cm，体重= 55.59 ±14.58公斤）大学生。干预：随机选择一个下肢进行热处理，而另一下肢不进行治疗。主要指标：我们每10分钟测量一次肌肉温度，通过两次相同的连续测量确定最高肌肉温度，并分析达到最高温度的时间。我们分析了腓肠肌和比目鱼肌中HSP70表达和HSP27P：T（HSP27与总HSP27表达的比率）的量，并测量了基线皮褶厚度和雌二醇水平。结果：与基线温度相比，流体疗法使肌内温度升高了5.66±0.788C（t11 = 25.67，P <.001），在84.17±6.69分钟时出现了39.08°C±0.398C的峰值温度。我们在腓肠肌或比目鱼肌中未发现HSP70或HSP27P：T的热处理效果（P> 0.05）。腓肠肌和比目鱼肌的峰值温度和HSP70的百分比变化呈正相关（P <.05）。我们发现皮褶厚度，性别或雌二醇水平没有其他相关性（P> 0.05）。未发现性别对基线的皮褶厚度或雌二醇水平有影响（P> .05）。结论：该流体疗法方案将肌内温度提高到治疗水平;但是，它不刺激比目鱼肌和腓肠肌的诱导型HSP70或HSP27P：T，无论性别或皮褶厚度如何。这些数据证实了流体疗法是一种有效的加热方式，但表明它不是刺激下肢HSP反应的有效方法。

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