Differences in solution dynamics between lens beta-crystallin homodimers and heterodimers probed by hydrogen-deuterium exchange and deamidation

Lampi Kirsten J.; Murray Matthew R.; Peterson Matthew P.; Eng Bryce S.; Yue Eileen; Clark Alice R.; Barbar Elisar; David Larry L.

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Differences in solution dynamics between lens beta-crystallin homodimers and heterodimers probed by hydrogen-deuterium exchange and deamidation

机译：氢-氘交换和脱酰胺法检测晶状体β-晶体蛋白同二聚体和异二聚体之间溶液动力学的差异

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Background: Lens transparency is due to the ordered arrangement of the major structural proteins, called aystallins. beta B2 crystallin in the lens of the eye readily forms dimers with other beta-crystallin subunits, but the resulting heterodimer structures are not known and were investigated in this study.

机译：背景：晶状体透明性是由于被称为aystallins的主要结构蛋白的有序排列所致。眼晶状体中的βB2晶状体蛋白容易与其他β-晶状体蛋白亚基形成二聚体，但尚不知道所得的异二聚体结构，并已在本研究中进行了研究。

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《Biochimica et Biophysica Acta. General Subjects》 |2016年第2期|共11页
作者
Lampi Kirsten J.; Murray Matthew R.; Peterson Matthew P.; Eng Bryce S.; Yue Eileen; Clark Alice R.; Barbar Elisar; David Larry L.;
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正文语种 eng
中图分类生物化学;
关键词
beta-Crystallins; Deamidation; Lens; Cataracts; Solution dynamics; Hydrogen-deuterium exchange; Mass spectrometry;

机译：β-晶状体;脱酰胺;透镜;白内障;溶液动力学;氢-氘交换;质谱;

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1. Differences in solution dynamics between lens beta-crystallin homodimers and heterodimers probed by hydrogen-deuterium exchange and deamidation [J] . Lampi Kirsten J., Murray Matthew R., Peterson Matthew P., Biochimica et Biophysica Acta. General Subjects . 2016,第1aPta2期

机译：氢-氘交换和脱酰胺法检测晶状体β-晶体蛋白同二聚体和异二聚体之间溶液动力学的差异
2. Na+/H+ Exchanger Regulatory Factor-1 Is Involved in Chemokine Receptor Homodimer CCR5 Internalization and Signal Transduction but Does Not Affect CXCR4 Homodimer or CXCR4-CCR5 Heterodimer [J] . Maha Hammad, Yi-Qun Kuang, Ronald Yan, The Journal of biological chemistry . 2010,第期

机译：Na + / H +交换剂调节因子-1参与趋化因子受体同源体CCR5内化和信号转导，但不影响CXCR4同源过二聚体或CXCR4-CCR5异二聚体
3. One-shot LC-MS/MS analysis of post-translational modifications including oxidation and deamidation of rat lens alpha- and beta-crystallins induced by gamma-irradiation [J] . Kim Ingu, Saito Takeshi, Fujii Norihiko, Amino acids . 2016,第12期

机译：翻译后修饰的单次LC-MS / MS分析，包括γ射线诱导的大鼠晶状体α-和β-晶状体蛋白的氧化和脱酰胺
4. Probing Higher Order Structural Changes of a Lysine-Linked Antibody-Drug Conjugate by Hydrogen-Deuterium Exchange Mass Spectrometry (HDXMS) [C] . Lintao Wang, Megan Bogalhas, Xuan Chen, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：氢 - 氘交换质谱（HDXMS）探测赖氨酸连接抗体 - 药物缀合物的高阶结构变化
5. Conformational analysis of C -terminal Src kinase: Regulation of activity probed by hydrogen-deuterium exchange and mass spectrometry. [D] . Wong, Lilly. 2004

机译：C末端Src激酶的构象分析：氢-氘交换和质谱探测的活性调节。
6. Differences in solution dynamics between lens β-crystallin homodimers and heterodimers probed by hydrogen–deuterium exchange and deamidation [O] . Kirsten J. Lampi, Matthew R. Murray, Matthew P. Peterson, -1

机译：氢-氘交换和脱酰胺法检测晶状体β-晶体蛋白同二聚体和异二聚体之间溶液动力学的差异
7. Differences in solution dynamics between lens β-crystallin homodimers and heterodimers probed by hydrogen-deuterium exchange and deamidation [O] . Lampi, K.J., Murray, M.R., Peterson, M.P., 2015

机译：氢-氘交换和脱酰胺法检测晶状体β-晶体蛋白同二聚体和异二聚体的溶液动力学差异

Differences in solution dynamics between lens beta-crystallin homodimers and heterodimers probed by hydrogen-deuterium exchange and deamidation

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