首页> 外文期刊>Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry >Metals in medicine: metal-related diseases-DNA sensing by lanthanide-binding peptides
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Metals in medicine: metal-related diseases-DNA sensing by lanthanide-binding peptides

机译:药物中的金属:与金属有关的疾病-镧系元素结合肽对DNA的传感

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摘要

DNA is a fascinating biomolecule, which is storing and dispensing genetic data required for life. Therefore, molecules that bind to DNA are extremely useful as biochemical tools to detect DNA both in vitro and inside the cell. Time-resolved luminescence of lanthanides is particularly attractive for applications of these ions as luminescent DNA probes, since it allows to eliminate the background natural fluorescence. Lanthanides-binding peptides are especially promising molecules for biological applications, since they provide high hydrophilicity and solubility in water to the probe.
机译:DNA是一种引人入胜的生物分子,它可以存储和分配生命所需的遗传数据。因此,与DNA结合的分子作为生化工具极其有用,可以在体外和细胞内检测DNA。镧系元素的时间分辨发光对于将这些离子用作发光DNA探针特别有吸引力,因为它可以消除背景自然荧光。镧系元素结合肽是生物学应用中特别有希望的分子,因为它们为探针提供了高亲水性和在水中的溶解性。

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