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首页> 外文期刊>Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry >Oral presentations-Investigation of metal complexes-RNA interaction
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Oral presentations-Investigation of metal complexes-RNA interaction

机译：口头报告-金属配合物研究-RNA相互作用

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摘要

The use of metal complexes as therapeutic and diagnostic agents is well acknowledged [1]. Depending on their chemical nature, these complexes can interact with their biological target via covalent and non-covalent binding [1]. The anticancer drug cisplatin and its derivatives belong to the first class of compounds, and are believed to mainly target DNA by preferentially binding to N7 atoms of guanine bases [2]. Conversely, various complexes studied as potential bioimaging agents belong to the second class, and show luminescence upon DNA intercalation [3]. In addition to DNA, metal complexes can also target other biomolecules, including RNA [4]. The latter is involved in several crucial biological processes and its structural diversity makes it an attractive target for the development of structure- selective RNA targeting molecules [5]. For example, platinum drugs can inhibit RNA dependent processes [4] and metal complexes with potential in bio-imaging were shown to accumulate in RNA-rich regions within the cell [6]. Nevertheless, information on metal containing molecules binding to RNA is still scarce.
机译：金属络合物作为治疗剂和诊断剂的使用是众所周知的[1]。根据它们的化学性质，这些复合物可以通过共价和非共价结合与其生物学靶标相互作用[1]。抗癌药顺铂及其衍生物属于第一类化合物，据信主要通过优先结合鸟嘌呤碱基的N7原子而靶向DNA [2]。相反，作为潜在的生物成像剂而研究的各种复合物属于第二类，并在DNA嵌入后显示出发光[3]。除了DNA以外，金属络合物还可以靶向其他生物分子，包括RNA [4]。后者涉及几个关键的生物学过程，其结构多样性使其成为开发结构选择性RNA靶向分子的有吸引力的靶标[5]。例如，铂类药物可以抑制RNA依赖性过程[4]，并且具有生物成像潜能的金属络合物已显示在细胞内富含RNA的区域中积聚[6]。尽管如此，有关与RNA结合的含金属分子的信息仍然很少。

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