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Metals in medicine: metal-related diseases-Interaction of hybrid polyoxometalates with biological targets

机译:医药中的金属:与金属有关的疾病-杂多金属氧酸盐与生物靶标的相互作用

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摘要

Polyoxometalates (POMs) are discrete and polyanionic metal-oxides with potential applications in medicine. Due to their redox and structural properties, indeed, they can affect electron transport within the cells and form adducts with macromolecules, via electrostatic interactions and hydrogen bonds. This behaviour has shown to be useful to denature proteins and inhibit enzymes, leading to antiviral, antitumoral and antibacterial activities [1].
机译:多金属氧酸盐(POM)是离散的聚阴离子金属氧化物,在医学中具有潜在应用。实际上,由于它们的氧化还原和结构特性,它们可以影响细胞内的电子传输,并通过静电相互作用和氢键与大分子形成加合物。已证明这种行为可用于使蛋白质变性和抑制酶,从而产生抗病毒,抗肿瘤和抗菌活性[1]。

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