• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry >Di- and polynuclear silver(I) saccharinate complexes of tertiary diphosphane ligands: synthesis, structures, in vitro DNA binding, and antibacterial and anticancer properties
【24h】

Di- and polynuclear silver(I) saccharinate complexes of tertiary diphosphane ligands: synthesis, structures, in vitro DNA binding, and antibacterial and anticancer properties

机译：叔二膦配体的双核和多核糖精银（I）糖精配合物：合成，结构，体外DNA结合以及抗菌和抗癌特性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A series of new silver(I) saccharinate (sac) complexes, [Ag_2(sac)_2(l-dppm)H_2O]·H_2O (1), {[Ag_2(l-sac)_2 (μ-dppe)]·3H_2O·CH_2Cl_2}_n (2), [Ag_2(μ-sac)_2(μ-dppp)]_n (3), and [Ag(sac)(μ-dppb)]_n (4) [dppm is 1,1-bis(diphenylphosphino) methane, dppe is 1,2-bis(diphenylphosphino) ethane, dppp is 1,3-bis(diphenylphosphino)propane, and dppb is 1,4-bis(diphenylphosphino)butane], have been synthesized and characterized by C, H, N elemental analysis, IR spectroscopy, ~1H NMR, ~(13)C NMR, and ~(31)P NMR spectroscopy, electrospray ionization mass spectrometry, and thermogravimetry– differential thermal analysis. Single-crystal X-ray studies show that the diphosphanes act as bridging ligands to yield a dinuclear complex (1) and one-dimensional coordination polymers (2 and 4),whereas the sac ligand adopts a μ2- N/O bridgingmode in 2, and is N-coordinated in 1 and 4. The interaction of the silver(I) complexes with fish sperm DNA was investigated using UV–vis spectroscopy, fluorescence spectroscopy, and agarose gel electrophoresis. The binding studies indicate that the silver(I) complexes can interact with fish spermDNA through intercalation, and complexes 1 and 3 have the highest binding affinity.The gel electrophoresis assay further confirms the binding of the complexes with the pBR322 plasmid DNA. The minimum inhibitory concentrations of the complexes indicate that complex 1 exhibits very high antibacterial activity against standard bacterial strains of Escherichia coli, Salmonella typhimurium, and Staphylococcus aureus, being much higher than those of AgNO_3, silver sulfadiazine, ciprofloxacin, and gentamicin. Moreover, complexes 1–3 exhibit very high cytotoxic activity against A549 and MCF-7 cancer cell lines, compared with AgNO3 and cisplatin. The bacterial and cell growth inhibitions of the silver(I) complexes are closely related to their DNA binding affinities.
机译：一系列新的糖精银（I）配合物[Ag_2（sac）_2（1-dppm）H_2O]·H_2O（1），{[Ag_2（1-sac）_2（μ-dppe）]·3H_2O ·CH_2Cl_2} _n（2），[Ag_2（μ-sac）_2（μ-dppp）] _ n（3）和[Ag（sac）（μ-dppb）] _ n（4）[dppm为1,1-双（二苯基膦基）甲烷，dppe是1,2-双（二苯基膦基）乙烷，dppp是1,3-双（二苯基膦基）丙烷，dppb是1,4-双（二苯基膦基）丁烷C，H，N元素分析，IR光谱，〜1H NMR，〜（13）C NMR和〜（31）P NMR光谱，电喷雾电离质谱和热重分析–差热分析。 X射线单晶研究表明，二膦类化合物作为桥联配体产生双核配合物（1）和一维配位聚合物（2和4），而囊状配体在2中采用μ2-N / O桥联模式，且在1和4中为N坐标。使用紫外可见光谱，荧光光谱和琼脂糖凝胶电泳研究了银（I）配合物与鱼精DNA的相互作用。结合研究表明，银（I）配合物可以通过插层与鱼精DNA相互作用，配合物1和3具有最高的结合亲和力。凝胶电泳分析进一步证实了配合物与pBR322质粒DNA的结合。配合物的最小抑制浓度表明配合物1对大肠杆菌，鼠伤寒沙门氏菌和金黄色葡萄球菌的标准细菌菌株表现出非常高的抗菌活性，远高于AgNO_3，磺胺嘧啶银，环丙沙星和庆大霉素。此外，与AgNO3和顺铂相比，复合物1-3对A549和MCF-7癌细胞具有很高的细胞毒活性。 silver（I）配合物的细菌和细胞生长抑制作用与其DNA结合亲和力密切相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号