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首页> 外文期刊>Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry >Metals in medicine: metal-related diseases-Diverse cytotoxic behaviour of cisplatin and oxaliplatinderived complexes involving kinetin moiety
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Metals in medicine: metal-related diseases-Diverse cytotoxic behaviour of cisplatin and oxaliplatinderived complexes involving kinetin moiety

机译：药物中的金属：与金属有关的疾病-涉及运动素的顺铂和奥沙利铂诱导的复合物的多种细胞毒性行为

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摘要

Platinum-containing therapeutics (e.g. cisplatin, oxaliplatin) have successfully been applied in medicine, however, have also shown undesirable side-effects and their use is connected with resistance of cancer cells [1]. The ongoing research in this field has proven that simple modification in the structure of platinum-based drugs does not guarantee desirable activity of the resulting compounds even in the first panel of testing, in vitro. For significant cytotoxicity, a suitable combination of the leaving and carrier ligands in the studied molecule is crucial.
机译：含铂的治疗药物（例如顺铂，奥沙利铂）已成功用于医学领域，但是也显示出不良的副作用，其使用与癌细胞的耐药性有关[1]。该领域正在进行的研究已经证明，即使在体外的第一批测试中，铂基药物结构的简单修饰也不能保证所得化合物的理想活性。对于显着的细胞毒性，所研究分子中离去配体和载体配体的合适组合至关重要。

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