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首页> 外文期刊>Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry >Session lectures-Siderophore iron uptake pathways in gram-negative bacteria
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Session lectures-Siderophore iron uptake pathways in gram-negative bacteria

机译：会议讲座-革兰氏阴性细菌中的五味子铁吸收途径

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摘要

Siderophores, are organic chelators produced by bacteria in order to get access to iron. Pseudomonas aeruginosa, a human opportunist pathogen, produces two major siderophores pyoverdine (PVD) and pyochelin (PCH), two molecules with very different chemical structures. These chelators are released in the environment of the bacteria, where they chelate iron with a very high affinity. Bacteria capture back the ferric forms of PVD and PCH from their environment and the uptake across the bacterial membranes involves highly siderophore specific transport proteins and molecular mechanisms. New insights in these molecular mechanisms involved in the ferri-siderophore capture and transport will be presented. Besides, we used chromosomal replacement to generate P. aeruginosa strains producing fluorescent fusions with proteins involved in PVD and PCH iron uptake pathways. These strains were used to investigate the expression of PVD and PCH pathways in planktonic and biofilm growth conditions, in order to understand why bacteria need and use several siderophore iron uptake pathways.
机译：铁载体，是细菌为了获取铁而产生的有机螯合剂。铜绿假单胞菌是一种人类机会病原体，可产生两种主要的铁载体吡弗定（PVD）和pyyochelin（PCH），这两种分子具有非常不同的化学结构。这些螯合剂在细菌环境中释放，在那里它们以非常高的亲和力螯合铁。细菌从其环境中捕获铁的形式的PVD和PCH，并且细菌膜上的摄取涉及高度铁载体的特异性转运蛋白和分子机制。将介绍有关铁亚铁载体捕获和转运的这些分子机制的新见解。此外，我们使用染色体置换产生了铜绿假单胞菌菌株，该菌株与参与PVD和PCH铁摄取途径的蛋白质产生了荧光融合。这些菌株用于研究浮游生物膜和生物膜生长条件下PVD和PCH途径的表达，以了解细菌为何需要并使用几种铁载体吸收铁的途径。

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