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首页> 外文期刊>The journal of asthma >The impact of uncontrolled asthma on absenteeism and health-related quality of life.
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The impact of uncontrolled asthma on absenteeism and health-related quality of life.

机译：不受控制的哮喘对旷工和与健康相关的生活质量的影响。

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OBJECTIVE: To evaluate the impact of uncontrolled asthma on the absenteeism and health-related quality of life (HRQOL) of adults and children with asthma and the caregivers of pediatric patients. PATIENTS AND METHODS: Patient information was obtained from datasets maintained by National Jewish Health for this cross-sectional study. Participants in the study were 12 years of age or older. Participants younger than 18 years had their information provided by caregivers. Caregivers also provided 6 months of absenteeism and QOL data. Participants were classified as having uncontrolled asthma based on a treatment and symptom guideline-based algorithm. Absenteeism was assessed from the self-reported number of work or school days missed due to asthma during the previous 6 months. HRQOL among adults was measured using the validated Marks Asthma Quality of Life Questionnaire (Marks-AQLQ) and among caregivers using the validated Pediatric Asthma Caregivers Quality of Life Questionnaire (PACQLQ). To account for the positive skew in absenteeism data, a zero-inflated Poisson regression model was used to compare group differences. HRQOL was analyzed for adults and caregivers using the Wilcoxon-Mann-Whitney test. RESULTS: A total of 15,149 patients met the inclusion criteria for the study and were included in the analysis. Adults with uncontrolled asthma and caregivers of children with uncontrolled asthma reported significantly higher absenteeism than their controlled counterparts: 43% vs 24% adults reported missing days of work, with a median 6 days vs 3 days missed; 31% vs 16% of caregivers reported missing days of work, with 4 days vs 2 days missed; and caregivers reported that more than 70% vs 45% pediatric patients missed school, with a median of 6 days vs 4 days missed (uncontrolled vs controlled asthma, respectively). Adult uncontrolled asthmatics and caregivers of uncontrolled pediatric patients had significantly lower HRQOL as indicated by the Marks-AQLQ (scores 1.5 points higher, p < 0.001) and PACQLQ (scores < 0.5 points lower, p < 0.001), respectively. CONCLUSIONS: Uncontrolled asthma has far-reaching impact on the productivity and quality of life of asthma patients and their caregivers. Proper assessment, treatment, and disease management to improve asthma control may reduce the impact of uncontrolled asthma on asthmatic adults, children, and the caretakers of pediatric asthmatic patients.
机译：目的：评估不受控制的哮喘对成人和儿童哮喘患儿以及小儿患者护理人员缺勤和健康相关生活质量（HRQOL）的影响。患者与方法：患者信息来自国家犹太人健康局为该横断面研究保留的数据集。该研究的参与者年龄在12岁以上。未满18岁的参与者的信息由看护人提供。护理人员还提供了6个月的缺勤和QOL数据。根据治疗和基于症状指南的算法，参与者被归类为患有不受控制的哮喘。根据过去6个月因哮喘而错过的工作或上学日的自我报告数量来评估旷工情况。成人成年人的HRQOL使用经过验证的马克斯哮喘生活质量问卷（Marks-AQLQ）进行测量，而看护者之间则通过经过验证的《小儿哮喘监护人生活质量问卷》（PACQLQ）进行测量。为了说明旷工数据中的正偏斜，使用了零膨胀的Poisson回归模型来比较组差异。使用Wilcoxon-Mann-Whitney检验对成人和护理人员的HRQOL进行了分析。结果：共有15149例患者符合研究纳入标准，并纳入分析。患有不受控制的哮喘的成年人和患有不受控制的哮喘的儿童的照料者的缺勤率明显高于受控制的同行者：43％vs 24％的成年人报告说他们缺少工作天，中位数为6天vs 3天。 31％的护理人员对16％的护理人员报告缺少工作天，其中4天比2天错过了。和护理人员报告说，超过70％的儿童（相对于45％）的儿童失学了，中位数分别为6天和4天（分别是不受控制的哮喘和控制的哮喘）。如Marks-AQLQ（得分高1.5分，p <0.001）和PACQLQ（得分低<0.5点，p <0.001）所示，成人不受控制的哮喘患者和小儿患者的护理人员的HRQOL显着降低。结论：不受控制的哮喘对哮喘患者及其护理人员的生产率和生活质量产生深远影响。适当的评估，治疗和疾病管理以改善哮喘控制能力，可以减少不受控制的哮喘对哮喘成年人，儿童和小儿哮喘患者看护者的影响。

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