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首页> 外文期刊>Journal of Bioinformatics and Computational Biology >Rotational dynamics of bases in the gene coding interferon alpha 17 (IFNA17)
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Rotational dynamics of bases in the gene coding interferon alpha 17 (IFNA17)

机译:干扰素α17(IFNA17)编码基因中碱基的旋转动力学

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摘要

In the present work, rotational oscillations of nitrogenous bases in the DNA with the sequence of the gene coding interferon alpha 17 (IFNA17), are investigated. As a mathematical model simulating oscillations of the bases, we use a system of two coupled nonlinear partial differential equations that takes into account effects of dissipation, action of external fields and dependence of the equation coefficients on the sequence of bases. We apply the methods of the theory of oscillations to solve the equations in the linear approach and to construct the dispersive curves determining the dependence of the frequency of the plane waves (omega) on the wave vector (q). In the nonlinear case, the solutions in the form of kink are considered, and the main characteristics of the kink: the rest energy (E-0), the rest mass (m(0)), the size (d) and sound velocity (C-0), are calculated. With the help of the energetic method, the kink velocity (upsilon), the path (S), and the lifetime (tau) are also obtained.
机译:在本工作中,研究了DNA中含氮碱基与编码干扰素α17(IFNA17)的基因序列的旋转振荡。作为模拟基础振动的数学模型,我们使用两个耦合的非线性偏微分方程组的系统,其中考虑了耗散效应,外部场的作用以及方程系数对基础序列的依赖性。我们应用振荡理论的方法来求解线性方法中的方程,并构建色散曲线,以确定平面波频率(ω)对波矢量(q)的依赖性。在非线性情况下,考虑扭结形式的解,并且扭结的主要特征为:静能量(E-0),静质量(m(0)),大小(d)和声速(C-0)进行计算。借助能量方法,还可以获得扭折速度(upsilon),路径(S)和寿命(tau)。

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