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首页> 外文期刊>The Journal of Bone and Joint Surgery. American Volume >Percutaneous injection of recombinant human bone morphogenetic protein-2 in a calcium phosphate paste accelerates healing of a canine tibial osteotomy.
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Percutaneous injection of recombinant human bone morphogenetic protein-2 in a calcium phosphate paste accelerates healing of a canine tibial osteotomy.

机译：在磷酸钙糊剂中经皮注射重组人骨形态发生蛋白2，可加速犬胫骨截骨术的愈合。

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BACKGROUND: In this study, we evaluated the capacity of a single percutaneous injection of recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered in a rapidly resorbable calcium phosphate paste (alpha-BSM) to accelerate bone-healing in a canine tibial osteotomy model. We hypothesized that the osteotomy sites would heal faster after percutaneous delivery of rhBMP-2/alpha-BSM than they would after injection of alpha-BSM alone or after no treatment. METHODS: Bilateral tibial osteotomy was performed and the sites were stabilized with external fixators in sixteen dogs. Four hours after the surgery, one limb of each dog was treated with a single percutaneous injection of rhBMP-2/alpha-BSM paste or an equal volume of alpha-BSM alone. There were eight limbs in each group, and the osteotomy site in the contralateral limb served as an untreated control. The results were evaluated with serial radiography and force-plate analysis at four and eight weeks after surgery and with mechanical testing and histologic examination at eight weeks after the surgery. RESULTS: At four and eight weeks after the osteotomy and treatment, the scores for radiographic union were significantly greater for the rhBMP-2/alpha-BSM-treated limbs than they were for the alpha-BSM-treated or untreated, control limbs (p < 0.05). The callus area in the rhBMP-2/alpha-BSM-treated limbs was significantly greater than that in the alpha-BSM-treated and untreated, control limbs at four and eight weeks postinjection (p < 0.05). The time-integrated vertical force for the rhBMP-2-treated limbs was significantly greater than that for their contralateral controls at four weeks and significantly greater than that for the treated and control limbs of the alpha-BSM-treated dogs at four and eight weeks after the surgery (p
机译：背景：在这项研究中，我们评估了快速可吸收的磷酸钙糊剂（alpha-BSM）中递送的重组人骨形态发生蛋白2（rhBMP-2）的单次经皮注射以加速犬胫骨的骨愈合的能力。截骨模型。我们假设，经皮递送rhBMP-2 / alpha-BSM后，截骨部位的愈合速度要比单独注射或未经治疗后的截骨部位愈合快。方法：对16只狗进行双侧胫骨截骨术，并用外固定架稳定该部位。手术后四小时，每只狗的一只肢体接受一次经皮注射rhBMP-2 /α-BSM糊剂或单独等量的α-BSM。每组有八个肢体，对侧肢体的截骨部位作为未治疗的对照。术后四周和八周通过连续射线照相术和测力板分析对结果进行评估，术后八周进行机械测试和组织学检查。结果：在截骨术和治疗后的第4和第8周，rhBMP-2 /α-BSM治疗的肢体的放射照相联合得分明显高于α-BSM治疗或未治疗的对照肢体（p <0.05）。 rhBMP-2 /α-BSM处理的肢体的愈伤组织面积在注射后四周和八周显着大于α-BSM处理和未经处理的对照肢体（p <0.05）。在4周时，rhBMP-2处理的肢体的时间积分垂直力显着大于对侧对照的水平力，在4周和8周时，显着大于alpha-BSM治疗犬的治疗和对照肢体的时间积分垂直力手术后（p

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