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首页> 外文期刊>Circulation: An Official Journal of the American Heart Association >Asymptomatic peripheral arterial disease is associated with more adverse lower extremity characteristics than intermittent claudication.
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Asymptomatic peripheral arterial disease is associated with more adverse lower extremity characteristics than intermittent claudication.

机译：与间歇性lau行相比，无症状的外周动脉疾病与下肢的不良反应更多。

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BACKGROUND: This study assessed functional performance, calf muscle characteristics, peripheral nerve function, and quality of life in asymptomatic persons with peripheral arterial disease (PAD). METHODS AND RESULTS: PAD participants (n=465) had an ankle brachial index <0.90. Non-PAD participants (n=292) had an ankle brachial index of 0.90 to 1.30. PAD participants were categorized into leg symptom groups including intermittent claudication (n=215) and always asymptomatic (participants who never experienced exertional leg pain, even during the 6-minute walk; n=72). Calf muscle was measured with computed tomography. Analyses were adjusted for age, sex, race, ankle brachial index, comorbidities, and other confounders. Compared with participants with intermittent claudication, always asymptomatic PAD participants had smaller calf muscle area (4935 versus 5592 mm(2); P<0.001), higher calf muscle percent fat (16.10% versus 9.45%; P<0.001), poorer 6-minute walk performance (966 versus 1129 ft; P=0.0002), slower usual-paced walking speed (P=0.0019), slower fast-paced walking speed (P<0.001), and a poorer Short-Form 36 Physical Functioning score (P=0.016). Compared with an age-matched, sedentary, non-PAD cohort, always asymptomatic PAD participants had smaller calf muscle area (5061 versus 5895 mm(2); P=0.009), poorer 6-minute walk performance (1126 versus 1452 ft; P<0.001), and poorer Walking Impairment Questionnaire speed scores (40.87 versus 57.78; P=0.001). CONCLUSIONS: Persons with PAD who never experience exertional leg symptoms have poorer functional performance, poorer quality of life, and more adverse calf muscle characteristics compared with persons with intermittent claudication and a sedentary, asymptomatic, age-matched group of non-PAD persons.
机译：背景：这项研究评估了无症状的外周动脉疾病（PAD）患者的功能表现，小腿肌肉特征，周围神经功能和生活质量。方法和结果：PAD参与者（n = 465）的踝臂指数<0.90。非PAD参与者（n = 292）的踝臂指数为0.90至1.30。 PAD参与者被分为腿部症状组，包括间歇性lau行（n = 215）和始终无症状（即使步行6分钟也从未经历劳累性腿痛的参与者; n = 72）。用计算机断层扫描测量小腿肌肉。对年龄，性别，种族，踝臂指数，合并症和其他混杂因素进行了分析调整。与间歇性lau行的参与者相比，无症状的PAD参与者的小腿肌肉面积较小（4935比5592 mm（2）; P <0.001），小腿肌肉脂肪百分比更高（16.10％比9.45％; P <0.001），较差的6-分钟步行性能（966对1129英尺; P = 0.0002），较慢的常规节奏行走速度（P = 0.0019），较慢的快节奏行走速度（P <0.001）和较差的短型36身体机能得分（P = 0.016）。与年龄相匹配的久坐，非PAD队列相比，总是无症状的PAD参与者的小腿肌肉面积较小（5061对5895 mm（2）; P = 0.009），6分钟步行表现较差（1126对1452 ft; P <0.001），以及步行障碍调查问卷速度评分较差（40.87对57.78; P = 0.001）。结论：与间歇性lau行和久坐，无症状，年龄匹配的非PAD患者相比，从未经历劳累性腿部症状的PAD患者的功能表现较差，生活质量较差，并且小腿肌肉特性较差。

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