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首页> 外文期刊>Journal of biochemical and molecular toxicology >Modulatory potential of ellagic acid, a natural plant polyphenol on altered lipid profile and lipid peroxidation status during alcohol-induced toxicity: a pathohistological study.
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Modulatory potential of ellagic acid, a natural plant polyphenol on altered lipid profile and lipid peroxidation status during alcohol-induced toxicity: a pathohistological study.

机译：鞣花酸（一种天然植物多酚）对酒精诱导的毒性过程中脂质谱和脂质过氧化状态改变的调节潜力：病理组织学研究。

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摘要

Polyphenol-rich dietary foodstuffs, consumed as an integral part of vegetables, fruits, and beverages have attracted attention due to their antioxidant and anticancer properties. Ellagic acid (EA), a polyphenolic compound widely distributed in fruits and nuts, has been reported to scavenge free radicals and inhibit lipid peroxidation. Chronic consumption of alcohol potentially results in serious illness including hepatitis, fatty liver, hypertriglyceridemia, and cirrhosis. A little is known about the influence of EA on alcohol toxicity in vivo. Accordingly, in the present study, we have evaluated the protective effects of EA on lipid peroxidation and lipid levels during alcohol-induced toxicity in experimental rats. Forty female albino Wistar rats, which were weighing between 150-170 g were used for the study. The toxicity was induced by administration of 20% alcohol orally (7.9 g/kg body wt.) for 45 days. Rats were treated with EA at three different doses (30, 60, and 90 mg/kg body wt.) via intragastric intubations together with alcohol. At the end of experimental duration, liver marker enzymes (i.e., aspartate transaminase, alanine transaminase), lipid peroxidative indices (i.e., thiobarbituriacid reactive substances and hydroperoxides) in plasma, and lipid levels (i.e., cholesterol, free fatty acids, triglycerides and phospholipids) in tissues were analyzed to evaluate the antiperoxidative and antilipidemic effects of EA. Liver marker enzymes, lipid peroxidative indices, and lipid levels, i.e., cholesterol, triglycerides and free fatty acids, were significantly increased whereas phospholipid levels were significantly decreased in the alcohol-administered group. EA treatment resulted in positive modulation of marker enzymes, peroxidative indices, and lipid levels. EA at the dose of 60 mg/kg body wt. was found to be more effective when compared to the other two doses. Histological changes observed were also inconsistent with the biochemical parameters. Our study suggests that EA exerts beneficial effects at the dosage of 60 mg/kg body wt. against alcohol-induced damage, and it can be used as a potential drug for the treatment of alcohol-abuse ailments in the near future.
机译：作为蔬菜，水果和饮料不可或缺的一部分，富含多酚的饮食食品因其抗氧化和抗癌特性而备受关注。据报道，鞣花酸（EA）是一种广泛分布于水果和坚果中的多酚化合物，据报道可以清除自由基并抑制脂质过氧化。长期饮酒可能导致严重的疾病，包括肝炎，脂肪肝，高甘油三酯血症和肝硬化。关于EA对体内酒精毒性的影响知之甚少。因此，在本研究中，我们评估了EA对酒精诱导的实验性大鼠脂质过氧化和脂质水平的保护作用。该研究使用了40只体重在150-170 g之间的白化Wistar雌性大鼠。通过口服20％的酒精（7.9 g / kg体重）45天诱发毒性。通过胃内插管和酒精，以三种不同剂量（30、60和90 mg / kg体重）的EA对大鼠进行治疗。实验持续时间结束时，血浆中的肝标志物酶（即天冬氨酸转氨酶，丙氨酸转氨酶），脂质过氧化指数（即硫代巴比妥酸反应性物质和氢过氧化物）和脂质水平（即胆固醇，游离脂肪酸，甘油三酸酯和磷脂） ）在组织中进行分析以评估EA的抗过氧化和抗血脂作用。在酒精给药组中，肝标记酶，脂质过氧化指数和脂质水平，即胆固醇，甘油三酸酯和游离脂肪酸显着增加，而磷脂水平显着降低。 EA处理导致标记酶，过氧化指数和脂质水平的正调节。 EA剂量为60 mg / kg体重。被发现与其他两种剂量相比更为有效。观察到的组织学变化也与生化参数不一致。我们的研究表明，EA以60 mg / kg体重的剂量发挥有益作用。防止酒精引起的损害，并且可以在不久的将来用作治疗酒精滥用疾病的潜在药物。

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