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首页> 外文期刊>Journal of biochemical and molecular toxicology >Effects of diallyl sulfide and zinc on testicular steroidogenesis in cadmium-treated male rats.
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Effects of diallyl sulfide and zinc on testicular steroidogenesis in cadmium-treated male rats.

机译：二烯丙基硫化物和锌对镉处理的雄性大鼠睾丸类固醇生成的影响。

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摘要

Cadmium (Cd) is one of the environmental pollutants that affect various tissues and organs including testis. Harmful effect of cadmium on testis is known to be germ cell degeneration and impairment of testicular steroidogenesis. In the present study, the effect of diallyl sulfide (DAS), a sulfur-containing volatile compound present in garlic, and zinc (Zn) was investigated on cadmium-induced testicular toxicity in rats. Male adult Wistar rats treated with cadmium (2.5 mg/kg body wt, five times a week for 4 weeks) showed decreased body weight, paired testicular weight, relative testicular weight, serum testosterone, luteinizing hormone, follicle-stimulating hormone, and testicular total antioxidant capacity (TAC) and protein levels. Testicular steroidogenic enzymes, such as 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD), and marker enzymes, such as sorbitol dehydrogenase (SDH), lactate dehydrogenase (LDH), acid phosphatase (ACP), alkaline phosphatase (ALP), and glucose-6-phosphate dehydrogenase (G6PD), showed a significant decrease in activities whereas that of gamma-glutamyl transferase was significantly increased after cadmium exposure. The results have revealed that concurrent treatment with DAS or zinc restored key steroidogenic enzymes, SDH, LDH, and G6PD and increased testicular weight significantly. DAS restored the TAC level and increased testosterone level and relative testicular weight significantly. Zinc restored testicular protein level and body weight. It can be concluded that cadmium causes testicular toxicity and inhibits androgen production in adult male rats probably by affecting pituitary gonadotrophins and that concurrent administration of DAS or zinc provides protection against cadmium-induced testicular toxicity.
机译：镉（Cd）是影响包括睾丸在内的各种组织和器官的环境污染物之一。已知镉对睾丸的有害作用是生殖细胞变性和睾丸类固醇生成受损。在本研究中，研究了大蒜中存在的含硫挥发性化合物二烯丙基硫化物（DAS）和锌（Zn）对镉诱导的大鼠睾丸毒性的影响。雄性成年Wistar大鼠用镉治疗（2.5 mg / kg体重，每周五次，连续4周），体重降低，配对睾丸重量，相对睾丸重量，血清睾丸激素，促黄体激素，促卵泡激素和睾丸总量降低抗氧化能力（TAC）和蛋白质水平。睾丸类固醇生成酶，例如3β-羟基类固醇脱氢酶（3beta-HSD）和17β-羟基类固醇脱氢酶（17beta-HSD），以及标记酶，例如山梨糖醇脱氢酶（SDH），乳酸脱氢酶（LDH），酸性磷酸酶（ACP），碱性磷酸酶（ALP）和葡萄糖-6-磷酸脱氢酶（G6PD）的活性显着降低，而γ-谷氨酰转移酶的活性在镉暴露后显着增加。结果表明，同时用DAS或锌治疗可恢复关键的类固醇生成酶，SDH，LDH和G6PD，并显着增加睾丸重量。 DAS可显着恢复TAC水平，并显着增加睾丸激素水平和相对睾丸重量。锌可恢复睾丸蛋白质水平和体重。可以得出结论，镉可能通过影响垂体促性腺激素而引起成年雄性大鼠睾丸毒性并抑制雄激素的产生，同时给予DAS或锌可提供抗镉诱导的睾丸毒性的保护作用。

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