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首页> 外文期刊>Journal of biochemical and molecular toxicology >Benfotiamine enhances antioxidant defenses and protects against cisplatin-induced DNA damage in nephrotoxic rats
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Benfotiamine enhances antioxidant defenses and protects against cisplatin-induced DNA damage in nephrotoxic rats

机译：Benfotiamine增强抗氧化剂防御能力，并保护顺铂对肾毒性大鼠的DNA损伤

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摘要

The objective of the present study was to assess superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), paraoxonase (PON1), glutathione reductase (GR), and catalase (CAT) activities ratio and their relationship with DNA oxidative damage in rats treated with cisplatin (3 mg/kg bwt/day) in the presence and absence of benfotiamine (100 mg/kg/day) for 25 days. Cisplatin-induced renal damage was evidenced by renal dysfunction and elevated oxidative stress markers. SOD activity and levels of nitric oxide, protein carbonyl, malondialdehyde, and 8-hydroxy-2'-deoxyguanosine were significantly increased by cisplatin treatment. Moreover, the ratios of GPx/GR, SOD/GPx, SOD/CAT, and SOD/PON1 were significantly increased compared to control. In contrast, glutathione levels were significantly decreased by cisplatin treatment. Simultaneous treatment of rats with cisplatin and benfotiamine ameliorate these variables to values near to those of control rats. This study suggests that benfotiamine can prevent cisplatin-induced nephrotoxicity by inhibiting formation reactive species of oxygen and nitrogen.
机译：本研究的目的是评估大鼠中的超氧化物歧化酶（SOD），过氧化氢酶，谷胱甘肽过氧化物酶（GPx），对氧磷酶（PON1），谷胱甘肽还原酶（GR）和过氧化氢酶（CAT）活性比及其与大鼠DNA氧化损伤的关系在存在和不存在苯丁胺（100 mg / kg /天）的情况下，用顺铂（3 mg / kg bwt /天）处理25天。肾功能不全和氧化应激指标升高证明了顺铂引起的肾损害。顺铂处理可显着提高SOD活性以及一氧化氮，蛋白质羰基，丙二醛和8-羟基-2'-脱氧鸟苷的水平。此外，与对照相比，GPx / GR，SOD / GPx，SOD / CAT和SOD / PON1的比率显着增加。相反，通过顺铂治疗可显着降低谷胱甘肽水平。同时用顺铂和苯甲酸安替他明治疗大鼠可将这些变量改善至接近对照大鼠的值。这项研究表明，苯乙胺明可以通过抑制氧和氮的形成反应性物质来预防顺铂诱导的肾毒性。

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