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首页> 外文期刊>Journal of biochemical and molecular toxicology >Curcumin Ameliorates Streptozotocin-Induced Heart Injury in Rats
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Curcumin Ameliorates Streptozotocin-Induced Heart Injury in Rats

机译：姜黄素改善大鼠链脲佐菌素引起的心脏损伤

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摘要

Heart failure (HF) is one of diabetic complications. This work was designed to investigate the possible modulatory effect of curcumin against streptozotocin-induced diabetes and consequently HF in rats. Rats were divided into control, vehicle-treated, curcumin-treated, diabetic-untreated, diabetic curcumin-treated, and diabetic glibenclamide-treated groups. Animal treatment was started 5 days after induction of diabetes and extended for 6 weeks. Diabetic rats showed significant increase in serum glucose, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, nitric oxide, lactate dehydrogenase, cardiac malondialdehyde, plasma levels of interleukin-6, and tumor necrosis factor-alpha, and also showed marked decrease in serum high-density lipoprotein-cholesterol, cardiac reduced glutathione, and cardiac antioxidant enzymes (catalase, superoxide dismutase, and glutathione-S-transferase). However, curcumin or glibenclamide treatment significantly mitigated such changes. In conclusion, curcumin has a beneficial therapeutic effect in diabetes-induced HF, an effect that might be attributable to its antioxidant and suppressive activity on cytokines.
机译：心力衰竭（HF）是糖尿病并发症之一。这项工作旨在研究姜黄素对链脲佐菌素诱导的糖尿病以及由此导致的HF在大鼠中的可能调节作用。将大鼠分为对照组，溶媒治疗，姜黄素治疗，糖尿病未治疗，糖尿病姜黄素治疗和糖尿病格列本脲治疗组。诱导糖尿病后5天开始进行动物治疗，并延长6周。糖尿病大鼠血清葡萄糖，甘油三酸酯，总胆固醇，低密度脂蛋白胆固醇，极低密度脂蛋白胆固醇，一氧化氮，乳酸脱氢酶，心脏丙二醛，白细胞介素6血浆水平和肿瘤坏死因子-α显着增加。 ，并且还显示血清高密度脂蛋白胆固醇，心脏还原型谷胱甘肽和心脏抗氧化酶（过氧化氢酶，超氧化物歧化酶和谷胱甘肽S-转移酶）明显降低。然而，姜黄素或格列本脲治疗显着减轻了这种改变。总之，姜黄素对糖尿病诱发的心衰具有有益的治疗作用，这种作用可能归因于其抗氧化剂和对细胞因子的抑制活性。

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