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首页> 外文期刊>Journal of biochemical and molecular toxicology >n-Octyl Gallate as Inhibitor of Pyruvate Carboxylation and Lactate Gluconeogenesis
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n-Octyl Gallate as Inhibitor of Pyruvate Carboxylation and Lactate Gluconeogenesis

机译：没食子酸正辛酯作为丙酮酸羧化和乳酸糖异生的抑制剂

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摘要

The alkyl gallates are found in several natural and industrial products. In the latter products, these compounds are added mainly for preventing oxidation. In the present work, the potencies of methyl gallate, n-propyl gallate, n-pentyl gallate, and n-octyl gallate as inhibitors of pyruvate carboxylation and lactate gluconeogenesis were evaluated. Experiments were done with isolated mitochondria and the isolated perfused rat liver. The potency of the gallic acid esters as inhibitors of pyruvate carboxylation in isolated mitochondria obeyed the following decreasing sequence: n-octyl gallate > n-pentyl gallate > n-propyl gallate > methyl gallate. A similar sequence of decreasing potency for lactate gluconeogenesis inhibition in the perfused liver was found in terms of the portal venous concentration. Both actions correlate with the lipophilicity of the compounds. The effects are harmful at high concentrations. At appropriate concentrations, however, octyl gallate should act therapeutically because its inhibitory action on gluconeogenesis will contribute further to its proposed antihyperglycemic effects.
机译：没食子酸烷基酯存在于几种天然和工业产品中。在后一种产品中，主要是为了防止氧化而添加这些化合物。在目前的工作中，评估了没食子酸甲酯，没食子酸正丙酯，没食子酸正戊酯和没食子酸正辛酯作为丙酮酸羧化和乳酸糖异生的抑制剂。用分离的线粒体和分离的灌注大鼠肝脏进行实验。没食子酸酯在分离的线粒体中作为丙酮酸羧化抑制剂的效力遵循以下递减顺序：没食子酸正辛酯>没食子酸正戊酯>没食子酸正丙酯>没食子酸甲酯。就门静脉浓度而言，在灌注肝脏中发现了抑制乳酸糖异生的能力下降的相似顺序。两种作用都与化合物的亲脂性有关。在高浓度下，这种作用是有害的。然而，在适当的浓度下，没食子酸辛酯应具有治疗作用，因为其对糖异生的抑制作用将进一步有助于其提议的降血糖作用。

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