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首页> 外文期刊>Journal of biochemical and molecular toxicology >Effects of the crotalus durissus terrificus snake venom on hepatic metabolism and oxidative stress.
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Effects of the crotalus durissus terrificus snake venom on hepatic metabolism and oxidative stress.

机译：响尾蛇蛇毒对肝脏代谢和氧化应激的影响。

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摘要

Snake venoms present different action mechanisms because of their complex composition, represented mainly by toxins and enzymes. This work aimed to investigate the effects of the Crotalus durissus terrificus(Cdt) venom in the liver. Wistar rats were inoculated intraperitoneally with saline (control) or Cdt venom. After 3, 4, or 6 h, the following parameters were analyzed: (a) hepatic function, (b) oxidative stress parameters, and (c) the metabolism of alanine in the isolated perfused liver. Plasma activities of alanine aminotransferase and aspartate aminotransferase and hepatic glutathione S-transferase and catalase presented significant elevation in rats inoculated with 300 mug kg(-1) Cdt venom. Liver lipoperoxidation was enormously increased by venom doses of 100, 200, and 300 mug kg(-1) , whereas glutathione S-transferase was not changed. Perfused livers from rats inoculated with 1500 mug kg(-1) venom showed increased production of lactate, pyruvate, and ammonia when alanine was the metabolic substrate. These results demonstrate that the Cdt venom can produce several changes in hepatocytes. The causes of the changes are possibly related to the disequilibrium in the redox homeostasis but also to specific needs of the poisoned organism, for example, an increased supply of lactate and pyruvate in response to an increased activity of the Cori cycle.
机译：由于蛇毒成分复杂，主要表现为毒素和酶，因此它们呈现出不同的作用机制。这项工作旨在调查猪屎豆（Ctaltal durissus terrificus（Cdt）毒液）在肝脏中的作用。 Wistar大鼠腹腔内接种生理盐水（对照组）或Cdt毒液。在3、4或6小时后，分析以下参数：（a）肝功能，（b）氧化应激参数，和（c）分离的灌注肝脏中丙氨酸的代谢。丙氨酸氨基转移酶和天冬氨酸氨基转移酶，肝谷胱甘肽S-转移酶和过氧化氢酶的血浆活性在接种了300杯kg（-1）Cdt毒液的大鼠中明显升高。分别以100、200和300马克杯kg（-1）的毒液剂量可大大增加肝脏的脂过氧化，而谷胱甘肽S-转移酶却没有改变。当丙氨酸为代谢底物时，用1500杯kg（-1）毒液接种的大鼠的灌注肝脏显示出乳酸，丙酮酸和氨的产生增加。这些结果表明，Cdt毒液可以在肝细胞中产生一些变化。变化的原因可能与氧化还原稳态的不平衡有关，但也与中毒生物体的特殊需要有关，例如，响应于Cori循环活性增加而增加的乳酸和丙酮酸供应。

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