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首页> 外文期刊>Journal of biochemical and molecular toxicology >Effect of neonatal exposure on male rats to bisphenol a on the expression of DNA methylation machinery in the postimplantation embryo
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Effect of neonatal exposure on male rats to bisphenol a on the expression of DNA methylation machinery in the postimplantation embryo

机译：新生仔鼠双酚a暴露对植入后胚胎DNA甲基化机制表达的影响

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摘要

Bisphenol A (BPA) is used in the production of polycarbonate plastics and epoxy resins. Our previous studies have demonstrated that neonatal exposure of male rats to BPA causes decrease in sperm count and motility, increase in postimplantation loss (POL), ultimately leading to subfertility during adulthood. Epigenetic mechanisms such as DNA methylation play an important role in embryo development. DNA methyltransferases (Dnmts) are the key players involved in regulating DNA methylation marks. The objective of the present study was to determine the mechanism involved in resorption of embryo as a result of BPA exposure. The results of the present study demonstrate that neonatal exposure of male rats to BPA down regulates the gene expression of Dnmts and related transcription factors in resorbed embryos as compared with the viable embryo. Thereby, suggesting that BPA may have altered the sperm epigenome, which might have affected the embryo development and leading to an increase in the POL.
机译：双酚A（BPA）用于生产聚碳酸酯塑料和环氧树脂。我们以前的研究表明，雄性大鼠的新生婴儿接触BPA会导致精子数量和运动能力下降，植入后损失（POL）增加，最终导致成年期的不育。表观遗传机制如DNA甲基化在胚胎发育中起重要作用。 DNA甲基转移酶（Dnmts）是参与调节DNA甲基化标记的关键因素。本研究的目的是确定与BPA接触导致胚胎再吸收的机制。本研究的结果表明，与有活力的胚胎相比，新生的雄性大鼠对BPA的初次暴露降低了Dnmts和相关转录因子的基因表达。因此，表明BPA可能改变了精子表观基因组，这可能影响了胚胎发育并导致POL升高。

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