...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biochemical and molecular toxicology >Mechanism of Dimercaptosuccinic Acid Coated Superparamagnetic Iron Oxide Nanoparticles with Human Serum Albumin
【24h】

Mechanism of Dimercaptosuccinic Acid Coated Superparamagnetic Iron Oxide Nanoparticles with Human Serum Albumin

机译：巯基琥珀酸包覆人血清白蛋白超顺磁性氧化铁纳米粒子的机理

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To research the mechanism of dimercaptosuccinic acid coated-superparamagnetic iron oxide nanoparticles (SPION) with human serum albumin (HSA), the methods of spectroscopy, molecular modeling calculation, and calorimetry were used in this paper. The inner filter effect of the fluorescence intensity was corrected to obtain the accurate results. Ultraviolet-visible absorption and circular dichroism spectra reflect that SPION changed the secondary structure with a loss of alpha-helix and loosened the protein skeleton of HSA; the activity of the protein was also affected by the increasing exposure of SPION. Fluorescence lifetime measurement indicates that the quenching mechanism type of this system was static quenching. The isothermal titration calorimetry measurement and molecular docking calculations prove that the predominant force of this system was the combination of Van der Waals' force and hydrogen bonds. (C) 2015 Wiley Periodicals, Inc.
机译：为了研究含人血清白蛋白（HSA）的二巯基琥珀酸包覆的超顺磁性氧化铁纳米粒子（SPION）的机理，本文使用了光谱学，分子模型计算和量热法。校正了荧光强度的内部过滤效果，以获得准确的结果。紫外线-可见吸收和圆二色性光谱反映出SPION改变了二级结构，失去了α-螺旋，并失去了HSA的蛋白质骨架。 SPION的暴露量也增加了蛋白质的活性。荧光寿命测量表明该系统的猝灭机理类型为静态猝灭。等温滴定量热法的测量和分子对接计算证明，该系统的主要作用力是范德华力与氢键的结合。 （C）2015年Wiley Periodicals，Inc.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号